RARA

Gene Symbol	RARA
Entrez Gene	5914
Alt Symbol	NR1B1, RAR
Species	Human
Gene Type	protein-coding
Description	retinoic acid receptor, alpha
Other Description	RAR-alpha|nuclear receptor subfamily 1 group B member 1|nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form|retinoic acid nuclear receptor alpha variant 1|retinoic acid nuclear receptor alpha variant 2|retinoic acid receptor alpha|retinoic acid receptor, alpha polypeptide
Swissprots	P78456 B8Y636 Q9NQS0 P10276
Accessions	AAD05222 AAD13888 AAF87249 CAA39533 CAM91168 EAW60652 EAW60653 EAW60654 EAW60655 EAW60656 EAW60657 EAW60658 P10276 AK098172 BAG53585 AK130192 AK292205 BAF84894 AK303868 BAG64806 AK312564 BAG35459 AL522713 AL834159 CAH56277 BC008727 AAH08727 BC071733 AAH71733 BG394590 BM838347 BM992549 BY799725 CB105313 CR457438 CAG33719 DA061829 DA541711 DQ893531 ABM84457 DQ893744 ABM84670 FJ487576 ACK86665 HQ692826 ADZ17337 HQ692827 ADZ17338 S50916 AAB19602 X06538 CAA29787 X06614 CAA29829 X58685 CAA41532 XM_005257552 XP_005257609 XM_005257553 XP_005257610 XM_005257554 XP_005257611 XM_011525095 XP_011523397 XM_011525096 XP_011523398 NM_000964 NP_000955 NM_001024809 NP_001019980 NM_001145301 NP_001138773 NM_001145302 NP_001138774 NM_001033603
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Top Pathways	Acute myeloid leukemia, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RARA-Over-expression-Lysate - LY10628a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

RARA overexpression lysate - LY428805 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RARA 293 Cell Lysate - 409752 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RARA 293 Cell Lysate - 400380 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RAR alpha/NR1B1 Overexpression Lysate (Native) - NBL1-15155 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RAR alpha/NR1B1 Overexpression Lysate (Native) - NBL1-15156 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RARα (h): 293T Lysate - sc-117323 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RARα (h3): 293T Lysate - sc-170472 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RARA Over-expression Lysate Product - GWB-99BD20 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

RARA Over-expression Lysate Product - GWB-368D14 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

RAR alpha/NR1B1 Overexpression Lysate (Native) - NBP2-11345 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human RARA Knockdown Stable Cell Line - CSC-DC012976 from Creative biogene Category Cell Line Species Human

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