| Gene Symbol | Il23r |
|---|---|
| Entrez Gene | 209590 |
| Alt Symbol | IL-23R |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 23 receptor |
| Other Description | IL-23 receptor|interleukin-23 receptor |
| Swissprots | Q8K4B4 |
| Accessions | EDK98806 Q8K4B4 AF461423 AAM44230 BC112425 AAI12426 NM_144548 NP_653131 |
| Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed by Th1, Th2 and dendritic cells. {ECO:0000269|PubMed:12023369}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD) |