Gene Symbol | Il23r |
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Entrez Gene | 209590 |
Alt Symbol | IL-23R |
Species | Mouse |
Gene Type | protein-coding |
Description | interleukin 23 receptor |
Other Description | IL-23 receptor|interleukin-23 receptor |
Swissprots | Q8K4B4 |
Accessions | EDK98806 Q8K4B4 AF461423 AAM44230 BC112425 AAI12426 NM_144548 NP_653131 |
Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed by Th1, Th2 and dendritic cells. {ECO:0000269|PubMed:12023369}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD) |
IL-23R CRISPR/Cas9 KO Plasmid (m) - sc-431652 from Santa Cruz Biotechnology
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IL-23R HDR Plasmid (m) - sc-431652-HDR from Santa Cruz Biotechnology
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IL-23R Double Nickase Plasmid (m) - sc-431652-NIC from Santa Cruz Biotechnology
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IL-23R Double Nickase Plasmid (m2) - sc-431652-NIC-2 from Santa Cruz Biotechnology
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IL-23R CRISPR Activation Plasmid (m) - sc-431652-ACT from Santa Cruz Biotechnology
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IL-23R CRISPR Activation Plasmid (m2) - sc-431652-ACT-2 from Santa Cruz Biotechnology
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IL-23R Lentiviral Activation Particles (m) - sc-431652-LAC from Santa Cruz Biotechnology
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IL-23R Lentiviral Activation Particles (m2) - sc-431652-LAC-2 from Santa Cruz Biotechnology
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IL-23R siRNA (m) - sc-60835 from Santa Cruz Biotechnology
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IL-23R shRNA Plasmid (m) - sc-60835-SH from Santa Cruz Biotechnology
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IL-23R shRNA (m) Lentiviral Particles - sc-60835-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33783 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33783 from Sigma-Aldrich
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IL23R siRNA (Mouse) - CRN1655 from Cohesion Biosciences
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IL23R - MBS8207415 from MyBioSource
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shRNA set against Mouse Il23r (NM_144548.1) - SHH318765 from Creative biogene
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shRNA set against Mouse Il23r(NM_144548.1) - SHL172574 from Creative biogene
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Mouse IL23R siRNA - orb291130 from Biorbyt
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IL23R shRNA Plasmid (Mouse) - CHN1655 from Cohesion Biosciences
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IL23R miRNA 3'UTR clone - MiUTR1M-06005 from Creative biogene
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