| Gene Symbol | ETS1 |
|---|---|
| Entrez Gene | 2113 |
| Alt Symbol | ETS-1, EWSR2, p54 |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
| Other Description | Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1|protein C-ets-1|v-ets avian erythroblastosis virus E2 oncogene homolog 1 |
| Swissprots | Q16080 P14921 A9UL17 F5GYX9 Q96AC5 Q14278 Q6N087 |
| Accessions | AAA52409 EAW67709 EAW67710 EAW67711 EAW67712 P14921 AK001630 AK291840 BAF84529 AK301405 BAG62940 AL832693 AY943926 AAY19514 BC017314 AAH17314 BG035366 BM468663 BP365215 BT019452 AAV38259 BT019453 AAV38260 BX640634 CAE45783 CA407336 CR542254 CAG47050 J04101 AAA52410 S53284 S67063 AAB28747 S87905 X14798 CAA32903 XM_011542649 XP_011540951 XM_011542650 XP_011540952 XM_011542651 XP_011540953 XM_011542652 XP_011540954 NM_001143820 NP_001137292 NM_001162422 NP_001155894 NM_005238 NP_005229 |
| Function | Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. |
| Tissue Specificity | Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. {ECO:0000269|PubMed:19377509, ECO:0000269|PubMed:20378371}. |
| Top Pathways | Renal cell carcinoma, HTLV-I infection, Dorso-ventral axis formation |
Ets-1 CRISPR/Cas9 KO Plasmid (h) - sc-400461 from Santa Cruz Biotechnology
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Ets-1 HDR Plasmid (h) - sc-400461-HDR from Santa Cruz Biotechnology
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Ets-1 Double Nickase Plasmid (h) - sc-400461-NIC from Santa Cruz Biotechnology
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Ets-1 Double Nickase Plasmid (h2) - sc-400461-NIC-2 from Santa Cruz Biotechnology
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Ets-1 CRISPR Activation Plasmid (h) - sc-400461-ACT from Santa Cruz Biotechnology
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Ets-1 CRISPR Activation Plasmid (h2) - sc-400461-ACT-2 from Santa Cruz Biotechnology
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Ets-1 Lentiviral Activation Particles (h) - sc-400461-LAC from Santa Cruz Biotechnology
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Ets-1 Lentiviral Activation Particles (h2) - sc-400461-LAC-2 from Santa Cruz Biotechnology
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Ets-1 siRNA (h) - sc-29309 from Santa Cruz Biotechnology
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Ets-1 shRNA Plasmid (h) - sc-29309-SH from Santa Cruz Biotechnology
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Ets-1 shRNA (h) Lentiviral Particles - sc-29309-V from Santa Cruz Biotechnology
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Ets-1 siRNA (h2) - sc-44259 from Santa Cruz Biotechnology
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Ets-1 shRNA Plasmid (h2) - sc-44259-SH from Santa Cruz Biotechnology
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Ets-1 shRNA (h2) Lentiviral Particles - sc-44259-V from Santa Cruz Biotechnology
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Ets-1 RNAi - H00002113-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1363 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1363 from Sigma-Aldrich
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ETS1 siRNA (Human) - CRH1466 from Cohesion Biosciences
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ETS1 - MBS8232264 from MyBioSource
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shRNA set against Human ETS1 (NM_005238.3) - SHH287649 from Creative biogene
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shRNA set against Human ETS1(NM_001143820.1) - SHH040297 from Creative biogene
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ETS1 shRNA Plasmid (Human) - CHH1466 from Cohesion Biosciences
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ETS1 miRNA 3'UTR clone - MiUTR1H-03324 from Creative biogene
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ETS1 miRNA 3'UTR clone - MiUTR4H-TG03183 from Creative biogene
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