Gene Symbol | KDM2B |
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Entrez Gene | 84678 |
Alt Symbol | CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2 |
Species | Human |
Gene Type | protein-coding |
Description | lysine (K)-specific demethylase 2B |
Other Description | CXXC-type zinc finger protein 2|F-box and leucine-rich repeat protein 10|F-box protein FBL10|F-box/LRR-repeat protein 10|JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein|[Histone-H3]-lysine-36 demethylase 1B|jmjC domain-containing histone demethylation protein 1B|jumonji C domain-containing histone demethylase 1B|lysine-specific demethylase 2B|protein-containing CXXC domain 2 |
Swissprots | Q96T03 A8MRS1 Q8NCI2 Q9NS96 Q96HC7 Q9UF75 Q96SL0 Q1RLM7 Q8NHM5 |
Accessions | EAW98266 EAW98267 EAW98268 Q8NHM5 AA504464 AB031230 BAA97672 AJ459424 CAD30700 AK027440 BAB55112 AK027692 BAB55301 AK074718 BAC11159 AK097933 AK127328 BAG54483 AK299827 BAG61696 AK316470 BAH14841 AL133572 CAB63721 BC008735 AAH08735 BC028612 BC115379 AAI15380 BC115380 AAI15381 BX648928 CA430876 XM_005253955 XP_005254012 XM_005253956 XP_005254013 XM_005253961 XP_005254018 XM_011538860 XP_011537162 XM_011538861 XP_011537163 XM_011538862 XP_011537164 XM_011538863 XP_011537165 XM_011538864 XP_011537166 XM_011538865 XP_011537167 XM_011538866 XP_011537168 XM_011538867 XP_011537169 XM_011538868 XP_011537170 XM_011538869 XP_011537171 XM_011538870 XP_011537172 XM_011538871 XP_011537173 XM_011538872 XP_011537174 XM_011538873 XP_011537175 XM_011538874 XP_011537176 XM_011538875 XP_011537177 XR_944787 NM_001005366 NP_001005366 NM_032590 NP_115979 |
Function | Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:17994099}. |
Active human KDM2B protein fragment - ab196435 from Abcam
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Human KDM2B peptide - ab30411 from Abcam
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Human KDM2B peptide - ab23079 from Abcam
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Human KDM2B protein fragment - ab164635 from Abcam
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KDM2B / FBXL10 Antibody Blocking Peptide - LS-E731 from LifeSpan Bioscience
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KDM2B / FBXL10 Antibody Blocking Peptide - LS-E25580 from LifeSpan Bioscience
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KDM2B / FBXL10 Antibody Blocking Peptide - LS-E14393 from LifeSpan Bioscience
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Recombinant Human KDM2B Protein - H00084678-Q01 from Novus Biologicals
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FBXL10b-Antibody-N-term-Blocking-peptide - BP11086a from Abgent, a WuXi AppTec company
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FBXL10 blocking peptide - GTX25199-PEP from GeneTex
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FBXL10 Blocking Peptide - 33R-5424 from Fitzgerald
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KDM2B Peptide - AC21-0409-P from Abcore
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KDM2B / FBXL10 - H00084678-Q01-10 from Acris Antibodies
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KDM2B / FBXL10 - H00084678-Q01-25 from Acris Antibodies
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FBXL10 Peptide - 45-574P from ProSci
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Recombinant FBXL10 / KDM2B protein - 31455 from ActiveMotif
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Recombinant Human KDM2B, FLAG-tagged - KDM2B-40H from Creative Biomart
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Recombinant Human Lysine-specific demethylase 2B(KDM2B) ,partial - CSB-YP836777HU CSB-EP836777HU CSB-BP836777HU CSB-MP836777HU from Cusabio
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FBXL10/PCCX2, Peptide - MBS425826 from MyBioSource
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Recombinant Human KDM2B protein, FLAG-tagged - KDM2B-457H from Creative Biomart
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KDM2B-Antibody-C-term-Blocking-peptide - BP2124e from Abgent, a WuXi AppTec company
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KDM2B-Antibody-N-term-Blocking-peptide - BP2124d from Abgent, a WuXi AppTec company
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FBXL10ab-Antibody-C-term-Blocking-peptide - BP2124b from Abgent, a WuXi AppTec company
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KDM2B-Antibody-N-term-Blocking-peptide - BP2124a from Abgent, a WuXi AppTec company
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KDM2B Peptide, Human - M34GP08042H from Creative Peptides
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