KDM2B

Gene Symbol KDM2B
Entrez Gene 84678
Alt Symbol CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 2B
Other Description CXXC-type zinc finger protein 2|F-box and leucine-rich repeat protein 10|F-box protein FBL10|F-box/LRR-repeat protein 10|JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein|[Histone-H3]-lysine-36 demethylase 1B|jmjC domain-containing histone demethylation protein 1B|jumonji C domain-containing histone demethylase 1B|lysine-specific demethylase 2B|protein-containing CXXC domain 2
Swissprots Q96T03 A8MRS1 Q8NCI2 Q9NS96 Q96HC7 Q9UF75 Q96SL0 Q1RLM7 Q8NHM5
Accessions EAW98266 EAW98267 EAW98268 Q8NHM5 AA504464 AB031230 BAA97672 AJ459424 CAD30700 AK027440 BAB55112 AK027692 BAB55301 AK074718 BAC11159 AK097933 AK127328 BAG54483 AK299827 BAG61696 AK316470 BAH14841 AL133572 CAB63721 BC008735 AAH08735 BC028612 BC115379 AAI15380 BC115380 AAI15381 BX648928 CA430876 XM_005253955 XP_005254012 XM_005253956 XP_005254013 XM_005253961 XP_005254018 XM_011538860 XP_011537162 XM_011538861 XP_011537163 XM_011538862 XP_011537164 XM_011538863 XP_011537165 XM_011538864 XP_011537166 XM_011538865 XP_011537167 XM_011538866 XP_011537168 XM_011538867 XP_011537169 XM_011538868 XP_011537170 XM_011538869 XP_011537171 XM_011538870 XP_011537172 XM_011538871 XP_011537173 XM_011538872 XP_011537174 XM_011538873 XP_011537175 XM_011538874 XP_011537176 XM_011538875 XP_011537177 XR_944787 NM_001005366 NP_001005366 NM_032590 NP_115979
Function Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:17994099}.

FBL10 CRISPR/Cas9 KO Plasmid (h) - sc-403232 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 HDR Plasmid (h) - sc-403232-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 Double Nickase Plasmid (h) - sc-403232-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 Double Nickase Plasmid (h2) - sc-403232-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 CRISPR Activation Plasmid (h) - sc-403232-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 CRISPR Activation Plasmid (h2) - sc-403232-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 Lentiviral Activation Particles (h) - sc-403232-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 Lentiviral Activation Particles (h2) - sc-403232-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 siRNA (h) - sc-75005 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL10 shRNA Plasmid (h) - sc-75005-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL10 shRNA (h) Lentiviral Particles - sc-75005-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KDM2B RNAi - H00084678-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU054301 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11027 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11027 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08666 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08666

KDM2B siRNA (Human) - CRJ3575 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KDM2B RNAi - H00084678-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

FBL10 CRISPR/Cas9 KO Plasmid (h2) - sc-403232-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL10 HDR Plasmid (h2) - sc-403232-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human KDM2B (NM_032590.4) - SHH324159 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FBXL10(NM_001005366.1) - SHH050717 from Creative biogene

Category siRNA
Species Reactivities Human

KDM2B shRNA Plasmid (Human) - CHJ3575 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KDM2B miRNA 3'UTR clone - MiUTR1H-03538 from Creative biogene

Species Reactivities Human

KDM2B miRNA 3'UTR clone - MiUTR3H-10389 from Creative biogene

Species Reactivities Human
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