| Gene Symbol |
Taok3
|
| Entrez Gene |
330177
|
| Alt Symbol |
2900006A08Rik, A130052D22, A430105I05Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TAO kinase 3
|
| Other Description |
serine/threonine-protein kinase TAO3|thousand and one amino acid protein 3
|
| Swissprots |
Q3V3B3 Q8BYC6
|
| Accessions |
Q8BYC6 AA182196 AK013486 AK037817 AK039665 BAE20549 AK040531 BAC30618 AK042181 BAE20625 AK138024 AK155208 AK170794 AK171353 BAE42407 AK188887 AK217809 BC158072 AAI58073 BM225493 BY201674 CK625948 XM_006530385 XP_006530448 XM_011248219 XP_011246521 XM_011248220 XP_011246522 XM_011248221 XP_011246523 NM_001081308 NP_001074777 NM_001199685 NP_001186614 NM_183306 NP_899129
|
| Function |
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway
|