| Gene Symbol | HMGCLL1 |
|---|---|
| Entrez Gene | 54511 |
| Alt Symbol | bA418P12.1, er-cHL |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 |
| Other Description | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic|3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1|3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1|endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase|probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 |
| Swissprots | B3KNV0 F8W793 B7Z1S7 B1AQ42 Q8TB92 Q6ZSA9 |
| Accessions | EAX04442 EAX04443 EAX04444 EAX04445 Q8TB92 AF131827 AAD20054 AK055075 BAG51462 AK127587 BAC87045 AK293856 BAH11613 AK294210 BAH11698 AK297191 BAH12520 AL137605 CAB70838 BC024194 AAH24194 DA508472 DB179645 HQ447228 ADQ31715 XM_011514700 XP_011513002 XM_011514701 XP_011513003 NM_001042406 NP_001035865 NM_001287741 NP_001274670 NM_001287746 NP_001274675 NM_001287753 NP_001274682 NM_019036 NP_061909 NR_109867 NR_109869 |
| Function | Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860}. |
| Subcellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. |
| Top Pathways | Peroxisome, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism |