HMGCLL1

Gene Symbol	HMGCLL1
Entrez Gene	54511
Alt Symbol	bA418P12.1, er-cHL
Species	Human
Gene Type	protein-coding
Description	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Other Description	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic|3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1|3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1|endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase|probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
Swissprots	B3KNV0 F8W793 B7Z1S7 B1AQ42 Q8TB92 Q6ZSA9
Accessions	EAX04442 EAX04443 EAX04444 EAX04445 Q8TB92 AF131827 AAD20054 AK055075 BAG51462 AK127587 BAC87045 AK293856 BAH11613 AK294210 BAH11698 AK297191 BAH12520 AL137605 CAB70838 BC024194 AAH24194 DA508472 DB179645 HQ447228 ADQ31715 XM_011514700 XP_011513002 XM_011514701 XP_011513003 NM_001042406 NP_001035865 NM_001287741 NP_001274670 NM_001287746 NP_001274675 NM_001287753 NP_001274682 NM_019036 NP_061909 NR_109867 NR_109869
Function	Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860}.
Subcellular Location	Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Peroxisome, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HMGCLL1 protein (His-DHFR tag) - ab127484 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

HMGCLL1 Antibody Blocking Peptide - LS-E20404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HMGCLL1 Protein - H00054511-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HMGCLL1 Blocking Peptide - 33R-6052 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HMGCLL1 - H00054511-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HMGCLL1 - H00054511-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HMGCLL1 fusion protein - Ag11541 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

HMGCLL1 fusion protein - ag10985 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HMGCLL1, His-tagged - HMGCLL1-13846H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2(HMGCLL1) - CSB-YP851531HU CSB-EP851531HU CSB-BP851531HU CSB-MP851531HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 (HMGCLL1), Recombinant Protein - MBS1314963 from MyBioSource Category Protein Prices $1,135.00, $1,135.00, $1,365.00, $1,365.00, $1,810.00, $1,810.00, $2,270.00, $2,270.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HMGC2-Antibody-Center-Blocking-peptide - BP5765c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HMGCLL1 Peptide, Human - M34GP07121H from Creative Peptides Category Peptide Source Synthetic. Species Human

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