Kit

Gene Symbol	Kit
Entrez Gene	16590
Alt Symbol	Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT
Species	Mouse
Gene Type	protein-coding
Description	kit oncogene
Other Description	Dominant white spotting|SCFR|Steel Factor Receptor|belly-spot|c-kit proto-oncogene protein|dominant spotting|mast/stem cell growth factor receptor Kit|proto-oncogene c-Kit|proto-oncogene tyrosine-protein kinase Kit|spotted sterile male|tyrosine-protein kinase Kit
Swissprots	Q6QJB8 Q6QJB7 Q6LEE9 Q61415 Q61417 Q8C8K9 Q61416 P05532 Q7TS86
Accessions	AAA37420 AAL37551 ACT22524 CAA46799 CAA46800 CAJ01232 CAJ15131 EDL37886 P05532 AK046795 BAC32872 AK047010 AK047175 AK145462 BAE26452 AW741410 AY536430 AAS45606 AY536431 AAS45607 BC026713 BC052457 AAH52457 BC075716 AAH75716 BY017579 BY123520 EF472963 ABP63541 X65997 CAA46798 Y00864 CAA68772 NM_001122733 NP_001116205 NM_021099 NP_066922
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT p
Subcellular Location	Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. {ECO:0000250}.
Tissue Specificity	Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells. {ECO:0000269|PubMed:1378413, ECO:0000269|PubMed:18447649, ECO:0000269|PubMed:7527401}.
Top Pathways	Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD117, Mouse, ELISA Kit - E03C2326 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Mast/stem cell growth factor receptor (KIT), Mouse, ELISA Kit - E03M0380 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Mast/stem cell growth factor receptor (Kit/Sl/CD117), Mouse, ELISA Kit - CSB-E17423m from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Mast/stem cell growth factor receptor Kit, Kit, Mouse, ELISA Kit - E0121m from ARP American Research Products Category ELISA Kit Prices $496.00 Sizes 96 t Range 0.156-10 ng/mL

Stem Cell Factor Receptor (SCFR), Mouse, ELISA Kit - SEA121Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

Stem Cell Factor Receptor, SCFR/CD117/C-kit, Mouse, ELISA Kit - YHB1256Mo from ARP American Research Products Category ELISA Kit

Mouse SCFR ELISA Kit - MS0247 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse SCFR(Stem Cell Factor Receptor) ELISA Kit - E-EL-M1091 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Mouse SCFR (Stem Cell Factor Receptor) CLIA Kit - E-CL-M0619 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Brain-gut peptides, ELISA Kit - MBS725356 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

mast/stem cell growth factor receptor (Kit/Sl/CD117) , ELISA Kit - MBS926215 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse KIT/SL/CD117 is typically less than 0.078 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.312 ng/ml -20 ng/ml.

SCFR, ELISA Kit - MBS2506980 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

Stem Cell Factor Receptor, SCFR/CD117/C-kit, ELISA Kit - MBS9302336 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse mast/stem cell growth factor receptor (Kit/Sl/CD117) ELISA Kit - CSB-E17423m from Cusabio Category ELISA Kit Sensitivity 0.078 ng/ml. Range 0.312 ng/ml-20 ng/ml

Mouse Stem Cell Factor Receptor ELISA - E03S0240 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Stem Cell Factor Receptor (SCFR) - SEA121Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse SCFR(Stem Cell Factor Receptor) ELISA Kit - E-EL-M1091 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Mouse Mast/stem cell growth factor receptor Kit ELISA Kit - abx254620 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Mouse SCFR ELISA Kit - abx154642 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Stem Cell Factor Receptor (SCFR), Mouse, ELISA Kit - DL-SCFR-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

SCFR (Stem Cell Factor Receptor), CLIA Kit - MBS2532198 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

MagniSort™ Mouse CD117 (c-Kit) Positive Selection Kit - 8802-6838 from eBioscience Prices $529.00 Sizes 200 tests

Mouse SCFR ELISA Kit - abx570364 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Mast/stem cell growth factor receptor Kit ELISA Kit - EKE51569 from Biomatik Category ELISA Kit Prices $570.40, $2,424.20, $4,563.20 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/mL

SCFR - EKM496 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

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