Kit
| Gene Symbol | Kit |
|---|---|
| Entrez Gene | 16590 |
| Alt Symbol | Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | kit oncogene |
| Other Description | Dominant white spotting|SCFR|Steel Factor Receptor|belly-spot|c-kit proto-oncogene protein|dominant spotting|mast/stem cell growth factor receptor Kit|proto-oncogene c-Kit|proto-oncogene tyrosine-protein kinase Kit|spotted sterile male|tyrosine-protein kinase Kit |
| Swissprots | Q6QJB8 Q6QJB7 Q6LEE9 Q61415 Q61417 Q8C8K9 Q61416 P05532 Q7TS86 |
| Accessions | AAA37420 AAL37551 ACT22524 CAA46799 CAA46800 CAJ01232 CAJ15131 EDL37886 P05532 AK046795 BAC32872 AK047010 AK047175 AK145462 BAE26452 AW741410 AY536430 AAS45606 AY536431 AAS45607 BC026713 BC052457 AAH52457 BC075716 AAH75716 BY017579 BY123520 EF472963 ABP63541 X65997 CAA46798 Y00864 CAA68772 NM_001122733 NP_001116205 NM_021099 NP_066922 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT p |
| Subcellular Location | Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. {ECO:0000250}. |
| Tissue Specificity | Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells. {ECO:0000269|PubMed:1378413, ECO:0000269|PubMed:18447649, ECO:0000269|PubMed:7527401}. |
| Top Pathways | Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Endocytosis |
Mouse-KIT-Antibody-Center-S739-Blocking-Peptide - BP18713c from Abgent, a WuXi AppTec company
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Mouse-KIT-Antibody-Center-Y719-Blocking-Peptide - BP18698c from Abgent, a WuXi AppTec company
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KIT-Antibody-C-term-S821Y823-Blocking-Peptide - BP19037b from Abgent, a WuXi AppTec company
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mouse-KIT-Antibody-Center-S716-Blocking-Peptide - BP19226c from Abgent, a WuXi AppTec company
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mouse-KIT-Antibody-Center-T357-Blocking-Peptide - BP19304c from Abgent, a WuXi AppTec company
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Phospho-mouse-KITY719-Antibody-Blocking-peptide - BP3784l from Abgent, a WuXi AppTec company
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Phospho-mouse-KITT357-Antibody-Blocking-peptide - BP3784f from Abgent, a WuXi AppTec company
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Phospho-mouse-KITS739-Antibody-Blocking-peptide - BP3784a from Abgent, a WuXi AppTec company
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Recombinant Mouse CD117/c-kit Fc Chimera, CF - 1356-SR-050 from R&D Systems
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Mouse c-Kit Fc tag protein - orb84069 from Biorbyt
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Mouse c-Kit His tag protein - orb84070 from Biorbyt
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Mouse SCFR Protein - abx069173 from Abbexa
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Stem Cell Factor Receptor (SCFR), Mouse - 20-6296 from ARP American Research Products
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Recombinant Mouse Kit, Fc tagged - Kit-4037M from Creative Biomart
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Recombinant Mouse Kit, His tagged - Kit-4038M from Creative Biomart
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Mouse CD117 Recombinant (SCFR) - RKP05532 from Reprokine
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Mouse c-kit / CD117 Protein (Fc Tag) - 50530-M02H-50 from Sino Biological
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Mouse c-kit / CD117 Protein (His Tag) - 50530-M08H-50 from Sino Biological
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Recombinant Stem Cell Factor Receptor (SCFR) - RPA121Mu01 from Cloud-clone
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Recombinant Stem Cell Factor Receptor (SCFR) - RPA121Mu02 from Cloud-clone
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Recombinant Mouse Mast/stem cell growth factor receptor Kit(Kit) - CSB-YP012375MO CSB-EP012375MO CSB-BP012375MO CSB-MP012375MO from Cusabio
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Recombinant Mouse CD117/c-kit Fc Chimera Protein, CF - 1356-SR from R&D Systems
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Recombinant Mouse c-kit / CD117 Protein (His tag) - PKSM040632 from Elabscience
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Recombinant Mouse c-kit / CD117 Protein (Fc tag)(Fc tag) - PKSM040633 from Elabscience
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Phospho-mouse-KITS716-Blocking-Peptide - BP3784q from Abgent, a WuXi AppTec company
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