| Gene Symbol |
Vcl
|
| Entrez Gene |
305679
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
vinculin
|
| Other Description |
metavinculin {ECO:0000250|UniProtKB:P18206}|vcl {ECO:0000250|UniProtKB:P18206}|vinculin {ECO:0000250|UniProtKB:P18206}
|
| Swissprots |
P85972 A6KKR4
|
| Accessions |
EDL86257 EDL86258 P85972 FQ229885 XM_006251639 XP_006251701 NM_001107248 NP_001100718
|
| Function |
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19343716}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P18206}. Cell membrane {ECO:0000250|UniProtKB:P18206}; Peripheral membrane protein {ECO:0000250|UniProtKB:P18206}; Cytoplasmic side {ECO:0000250|UniProtKB:P18206}. Cell junction, focal adhesion {ECO:0000250}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. Colocalizes with LIMD1 in the focal adhesions (By similarity). {ECO:0000250}.
|
| Top Pathways |
Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Bacterial invasion of epithelial cells, Amoebiasis
|