Gene Symbol | Vcl |
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Entrez Gene | 305679 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | vinculin |
Other Description | metavinculin {ECO:0000250|UniProtKB:P18206}|vcl {ECO:0000250|UniProtKB:P18206}|vinculin {ECO:0000250|UniProtKB:P18206} |
Swissprots | P85972 A6KKR4 |
Accessions | EDL86257 EDL86258 P85972 FQ229885 XM_006251639 XP_006251701 NM_001107248 NP_001100718 |
Function | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19343716}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P18206}. Cell membrane {ECO:0000250|UniProtKB:P18206}; Peripheral membrane protein {ECO:0000250|UniProtKB:P18206}; Cytoplasmic side {ECO:0000250|UniProtKB:P18206}. Cell junction, focal adhesion {ECO:0000250}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. Colocalizes with LIMD1 in the focal adhesions (By similarity). {ECO:0000250}. |
Top Pathways | Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Bacterial invasion of epithelial cells, Amoebiasis |
vinculin siRNA (r) - sc-270542 from Santa Cruz Biotechnology
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vinculin shRNA Plasmid (r) - sc-270542-SH from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN65128 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND65128 from Sigma-Aldrich
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VCL siRNA (Rat) - CRR5003 from Cohesion Biosciences
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VCL - MBS8230852 from MyBioSource
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shRNA set against Rat VCL (NM_001107248.1) - SHH442452 from Creative biogene
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VCL shRNA Plasmid (Rat) - CHR5003 from Cohesion Biosciences
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VCL miRNA 3'UTR clone - MiUTR1R-08506 from Creative biogene
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