LIMK1

Gene Symbol	LIMK1
Entrez Gene	3984
Alt Symbol	LIMK, LIMK-1
Species	Human
Gene Type	protein-coding
Description	LIM domain kinase 1
Other Description	LIM motif-containing protein kinase
Swissprots	Q15821 B7Z6I8 Q75MU3 Q15820 D3DXF5 O15283 P53667 D3DXF4 Q9Y5Q1
Accessions	AAB17545 AAB17546 AAC13885 AAC13886 AAS07436 AAS07437 AAS07438 EAW69620 EAW69621 EAW69622 EAW69623 P53667 AB209557 BAD92794 AF134379 AAD25742 AK026544 AK125156 AK290162 BAF82851 AK300382 BAH13274 AW016257 BC148340 AAI48341 BC152982 AAI52983 D26309 BAA05371 DC296332 NM_001204426 NP_001191355 NM_002314 NP_002305 NM_016735
Function	Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin- 2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phospho
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm.
Tissue Specificity	Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
Top Pathways	Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human LIM Kinase 1 protein fragment - ab70186 from Abcam Category Protein Prices $239.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Active human LIMK1 protein fragment - ab174066 from Abcam Category Protein Prices $238.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human LIM Kinase 1 full length protein - ab132878 from Abcam Category Protein Source Wheat germ Species Human

Human LIM Kinase 1 protein fragment - ab158818 from Abcam Category Protein Source Wheat germ Species Human

LIMK1 peptide - ab90604 from Abcam Category Peptide

LIMK1 / LIMK Antibody Blocking Peptide - LS-E7480 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIMK1 / LIMK Antibody Blocking Peptide - LS-E9286 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LIM Kinase 1 Protein - H00003984-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LIM Kinase 1 Protein - H00003984-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

LIM Kinase 1 Peptide - P2827 from Novus Biologicals Category Peptide Species Human

LIMK1-Thr508-antibody-Blocking-peptide - BP10416a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-LIMK1Thr508-Antibody-Blocking-peptide - BP3745a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

LIM-Kinase-1-LIMK1-Antibody-N-term-Blocking-peptide - BP7813a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LIMK1; LIMK2 peptide - orb219119 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken

LIMK1 peptide - orb217549 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

LIMK1 Blocking Peptide - abx062878 from Abbexa Category Peptide Species Human, Mouse, Rat

LIMK1/2 (phospho-Thr508/505) Blocking Peptide - abx062879 from Abbexa Category Peptide Species Human, Rat, Bovine, Chicken

LIMK1/2 (phospho-Thr508/505) Blocking Peptide - abx062880 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken

LIMK1/2 Blocking Peptide - abx062150 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken

LIMK1 - H00003984-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

LIMK1 - H00003984-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

LIMK1 - H00003984-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LIMK1 - H00003984-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LIMK1 - P5575 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

LIMK1 fusion protein - ag16220 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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