LIMK1

Gene Symbol	LIMK1
Entrez Gene	3984
Alt Symbol	LIMK, LIMK-1
Species	Human
Gene Type	protein-coding
Description	LIM domain kinase 1
Other Description	LIM motif-containing protein kinase
Swissprots	Q15821 B7Z6I8 Q75MU3 Q15820 D3DXF5 O15283 P53667 D3DXF4 Q9Y5Q1
Accessions	AAB17545 AAB17546 AAC13885 AAC13886 AAS07436 AAS07437 AAS07438 EAW69620 EAW69621 EAW69622 EAW69623 P53667 AB209557 BAD92794 AF134379 AAD25742 AK026544 AK125156 AK290162 BAF82851 AK300382 BAH13274 AW016257 BC148340 AAI48341 BC152982 AAI52983 D26309 BAA05371 DC296332 NM_001204426 NP_001191355 NM_002314 NP_002305 NM_016735
Function	Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin- 2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phospho
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm.
Tissue Specificity	Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
Top Pathways	Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® LIMK1 siRNA II - 7156 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® LIMK1 siRNA I - 4559 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

LIMK-1 CRISPR/Cas9 KO Plasmid (h) - sc-401057 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 HDR Plasmid (h) - sc-401057-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 Double Nickase Plasmid (h) - sc-401057-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 Double Nickase Plasmid (h2) - sc-401057-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 CRISPR Activation Plasmid (h) - sc-401057-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 CRISPR Activation Plasmid (h2) - sc-401057-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 Lentiviral Activation Particles (h) - sc-401057-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 Lentiviral Activation Particles (h2) - sc-401057-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LIMK-1 siRNA (h) - sc-35810 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LIMK-1 shRNA Plasmid (h) - sc-35810-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LIMK-1 shRNA (h) Lentiviral Particles - sc-35810-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LIM Kinase 1 RNAi - H00003984-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU073301 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1052 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1051 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1050 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2073 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2073 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09027 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09027

LIMK1 siRNA (Human) - CRH2697 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

LIM Kinase 1 RNAi - H00003984-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Human LIMK1 siRNA - orb263199 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

LIMK1 shRNA Plasmid (Human) - CHH2697 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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