| Gene Symbol |
Slc29a4
|
| Entrez Gene |
243328
|
| Alt Symbol |
ENT4, mPMAT
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 29 (nucleoside transporters), member 4
|
| Other Description |
equilibrative nucleoside transporter 4|solute carrier family 29 member 4
|
| Swissprots |
Q8R139
|
| Accessions |
Q8R139 BC025599 AAH25599 BY727407 XM_006504706 XP_006504769 XM_006504707 XP_006504770 XM_011240982 XP_011239284 NM_146257 NP_666369
|
| Function |
Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorptprev reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sens
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart. {ECO:0000269|PubMed:16873718}.
|