| Gene Symbol | Slc29a4 |
|---|---|
| Entrez Gene | 243328 |
| Alt Symbol | ENT4, mPMAT |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | solute carrier family 29 (nucleoside transporters), member 4 |
| Other Description | equilibrative nucleoside transporter 4|solute carrier family 29 member 4 |
| Swissprots | Q8R139 |
| Accessions | Q8R139 BC025599 AAH25599 BY727407 XM_006504706 XP_006504769 XM_006504707 XP_006504770 XM_011240982 XP_011239284 NM_146257 NP_666369 |
| Function | Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorptprev reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sens |
| Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in heart. {ECO:0000269|PubMed:16873718}. |
ENT4 CRISPR/Cas9 KO Plasmid (m) - sc-433966 from Santa Cruz Biotechnology
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ENT4 HDR Plasmid (m) - sc-433966-HDR from Santa Cruz Biotechnology
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ENT4 Double Nickase Plasmid (m) - sc-433966-NIC from Santa Cruz Biotechnology
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ENT4 Double Nickase Plasmid (m2) - sc-433966-NIC-2 from Santa Cruz Biotechnology
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ENT4 CRISPR Activation Plasmid (m) - sc-433966-ACT from Santa Cruz Biotechnology
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ENT4 CRISPR Activation Plasmid (m2) - sc-433966-ACT-2 from Santa Cruz Biotechnology
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ENT4 Lentiviral Activation Particles (m) - sc-433966-LAC from Santa Cruz Biotechnology
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ENT4 Lentiviral Activation Particles (m2) - sc-433966-LAC-2 from Santa Cruz Biotechnology
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ENT4 siRNA (m) - sc-144898 from Santa Cruz Biotechnology
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ENT4 shRNA Plasmid (m) - sc-144898-SH from Santa Cruz Biotechnology
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ENT4 shRNA (m) Lentiviral Particles - sc-144898-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU071871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN41406 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41406 from Sigma-Aldrich
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SLC29A4 siRNA (Mouse) - CRN3654 from Cohesion Biosciences
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SLC29A4 - MBS8220240 from MyBioSource
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shRNA set against Mouse SLC29A4 (NM_146257.2) - SHH410188 from Creative biogene
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shRNA set against Mouse Slc29a4(NM_146257.2) - SHL005354 from Creative biogene
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SLC29A4 shRNA Plasmid (Mouse) - CHN3654 from Cohesion Biosciences
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SLC29A4 miRNA 3'UTR clone - MiUTR1M-10837 from Creative biogene
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