Gene Symbol | Kiss1r |
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Entrez Gene | 114229 |
Alt Symbol | Gpr54, KiSS-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | KISS1 receptor |
Other Description | G protein-coupled receptor 54|G-protein coupled receptor 54|G-protein coupled receptor OT7T175|kiSS-1 receptor|kiSS-1R|kisspeptins receptor|mOT7T175|metastin receptor|orphan G protein-coupled receptor 54 |
Swissprots | Q91V45 Q8K3P2 |
Accessions | EDL31625 EDL31626 Q91V45 AF343726 AAK83236 AK039628 BAC30404 AK139303 AY044228 AAK95814 BC016531 AAH16531 EU532436 ACB56625 EU532437 ACB56626 EU879091 ACI46599 GU075727 ACY56024 XM_006513076 XP_006513139 XM_006513077 XP_006513140 XM_006513078 XP_006513141 XM_006513079 XP_006513142 XM_006513080 XP_006513143 XR_380346 NM_053244 NP_444474 |
Function | Receptor for metastin (kisspeptin-52 or kp-52), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin- released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. {ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:12359743, ECO:0000269|PubMed:15665093}. |
Top Pathways | Neuroactive ligand-receptor interaction |
KiSS-1 receptor, Kiss1r, Mouse, ELISA Kit - E2140m from ARP American Research Products
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Kisspeptin Receptor (KISS1R), Mouse, ELISA Kit - SEF540Mu from ARP American Research Products
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Metastasis-suppressor KiSS-1 (KISS1), Mouse, ELISA Kit - CSB-EL012373MO from ARP American Research Products
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ELISA Kit for Kisspeptin Receptor (KISS1R) - SEF540Mu from Cloud-clone
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Kisspeptin Receptor (KISS1R), Mouse, ELISA Kit - DL-KISS1R-Mu from ARP American Research Products
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Mouse KISS1R ELISA Kit - abx571570 from Abbexa
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Mouse KiSS-1 receptor ELISA Kit - E053700 from Biobool
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Mouse Kiss1r ELISA Kit - E058100 from Biobool
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Mouse KISS-1 ELISA Kit - E058102 from Biobool
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KISS1R ELISA Kit (Mouse) (OKCD02669) - OKCD02669 from Aviva Systems Biology
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Mouse Metastasis-suppressor KiSS-1 (KISS1) ELISA Kit - AE36672MO from ARP American Research Products
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KiSS-1 receptor, ELISA Kit - MBS2882826 from MyBioSource
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Kisspeptin Receptor (KISS1R), ELISA Kit - MBS452101 from MyBioSource
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