| Gene Symbol |
Kiss1r
|
| Entrez Gene |
114229
|
| Alt Symbol |
Gpr54, KiSS-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
KISS1 receptor
|
| Other Description |
G protein-coupled receptor 54|G-protein coupled receptor 54|G-protein coupled receptor OT7T175|kiSS-1 receptor|kiSS-1R|kisspeptins receptor|mOT7T175|metastin receptor|orphan G protein-coupled receptor 54
|
| Swissprots |
Q91V45 Q8K3P2
|
| Accessions |
EDL31625 EDL31626 Q91V45 AF343726 AAK83236 AK039628 BAC30404 AK139303 AY044228 AAK95814 BC016531 AAH16531 EU532436 ACB56625 EU532437 ACB56626 EU879091 ACI46599 GU075727 ACY56024 XM_006513076 XP_006513139 XM_006513077 XP_006513140 XM_006513078 XP_006513141 XM_006513079 XP_006513142 XM_006513080 XP_006513143 XR_380346 NM_053244 NP_444474
|
| Function |
Receptor for metastin (kisspeptin-52 or kp-52), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin- released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. {ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:12359743, ECO:0000269|PubMed:15665093}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|