Gene Symbol | Kiss1r |
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Entrez Gene | 114229 |
Alt Symbol | Gpr54, KiSS-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | KISS1 receptor |
Other Description | G protein-coupled receptor 54|G-protein coupled receptor 54|G-protein coupled receptor OT7T175|kiSS-1 receptor|kiSS-1R|kisspeptins receptor|mOT7T175|metastin receptor|orphan G protein-coupled receptor 54 |
Swissprots | Q91V45 Q8K3P2 |
Accessions | EDL31625 EDL31626 Q91V45 AF343726 AAK83236 AK039628 BAC30404 AK139303 AY044228 AAK95814 BC016531 AAH16531 EU532436 ACB56625 EU532437 ACB56626 EU879091 ACI46599 GU075727 ACY56024 XM_006513076 XP_006513139 XM_006513077 XP_006513140 XM_006513078 XP_006513141 XM_006513079 XP_006513142 XM_006513080 XP_006513143 XR_380346 NM_053244 NP_444474 |
Function | Receptor for metastin (kisspeptin-52 or kp-52), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin- released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. {ECO:0000269|PubMed:11414709, ECO:0000269|PubMed:12359743, ECO:0000269|PubMed:15665093}. |
Top Pathways | Neuroactive ligand-receptor interaction |
GPR54 CRISPR/Cas9 KO Plasmid (m) - sc-431097 from Santa Cruz Biotechnology
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GPR54 HDR Plasmid (m) - sc-431097-HDR from Santa Cruz Biotechnology
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GPR54 Double Nickase Plasmid (m) - sc-431097-NIC from Santa Cruz Biotechnology
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GPR54 Double Nickase Plasmid (m2) - sc-431097-NIC-2 from Santa Cruz Biotechnology
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GPR54 CRISPR Activation Plasmid (m) - sc-431097-ACT from Santa Cruz Biotechnology
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GPR54 CRISPR Activation Plasmid (m2) - sc-431097-ACT-2 from Santa Cruz Biotechnology
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GPR54 Lentiviral Activation Particles (m) - sc-431097-LAC from Santa Cruz Biotechnology
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GPR54 Lentiviral Activation Particles (m2) - sc-431097-LAC-2 from Santa Cruz Biotechnology
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GPR54 siRNA (m) - sc-60748 from Santa Cruz Biotechnology
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GPR54 shRNA Plasmid (m) - sc-60748-SH from Santa Cruz Biotechnology
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GPR54 shRNA (m) Lentiviral Particles - sc-60748-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU009131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34311 from Sigma-Aldrich
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KISS1R siRNA (Mouse) - CRN1178 from Cohesion Biosciences
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shRNA set against Mouse KISS1R (NM_053244.5) - SHH325595 from Creative biogene
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Mouse KISS1R siRNA - orb290653 from Biorbyt
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KISS1R shRNA Plasmid (Mouse) - CHN1178 from Cohesion Biosciences
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