GSK3B

Gene Symbol	GSK3B
Entrez Gene	2932
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 beta
Other Description	GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B
Swissprots	Q9UL47 D3DN89 Q9BWH3 P49841
Accessions	AAC69340 AAD48517 CBX51856 CBX51857 CBX51858 CBX51859 EAW79533 EAW79534 EAW79535 EAW79536 P49841 AB451356 BAG70170 AK290897 BAF83586 AY123976 AAM88578 BC000251 AAH00251 BC012760 AAH12760 BX640779 CA312249 CR536510 CAG38748 DA477189 DQ892501 ABM83427 DQ895714 ABM86640 EU302497 ABX89591 L33801 AAA66475 XM_006713610 XP_006713673 XM_006713611 XP_006713674 NM_001146156 NP_001139628 NM_002093 NP_002084
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.
Tissue Specificity	Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}.
Top Pathways	Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-GSK-3β (Ser9) Sandwich ELISA Kit - 7311 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total GSK-3β Sandwich ELISA Kit - 7265 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

GSK3 beta (GSK3B) ELISA Kit - ab123454 from Abcam Category ELISA Kit Sensitivity 0.7 ng/ml Range 1.56 ng/ml - 100 ng/ml

GSK3 beta (pS9) PhosphoTracer ELISA Kit - ab119628 from Abcam Category ELISA Kit Sensitivity 0.15 ng/ml Range 0.15 ng/ml - 500 ng/ml

GSK3 beta pSer9 + Total PhosphoTracer ELISA kit - ab119660 from Abcam Category ELISA Kit

GSK3 beta Total PhosphoTracer ELISA Kit - ab119629 from Abcam Category ELISA Kit Sensitivity 0.15 ng/ml Range 0.15 ng/ml - 500 ng/ml

GSK3B pTyr216 Profiling ELISA Kit - ab173189 from Abcam Category ELISA Kit Sensitivity 12.5 µg/ml Range 31.2 µg/ml - 2000 µg/ml

Mouse/Human/Rat GSK3B / GSK3 Beta ELISA Kit (Cell-Based ELISA) - LS-F2031 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-GSK3B / GSK3 Beta (Ser9) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1521 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Human GSK3B / GSK3 Beta ELISA Kit (Sandwich ELISA) - LS-F7655 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.227 ng/ml Range 0.156-10 ng/ml

Rat GSK3B / GSK3 Beta ELISA Kit (Sandwich ELISA) - LS-F7877 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.29 ng/ml Range 0.156-10 ng/ml

Rat GSK3B / GSK3 Beta ELISA Kit (Sandwich ELISA) - LS-F11585 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.156-10 ng/ml

Human GSK3B / GSK3 Beta ELISA Kit (Sandwich ELISA) - LS-F11584 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Rabbit anti-GSK3-beta Antibody, Affinity Purified - PLA0232 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Phospho-GSK-3 beta (S9) DuoSet IC ELISA, 2 Plate - DYC1590-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 312.00 - 20,000 pg/mL

Phospho-GSK-3 beta (S9) DuoSet IC, 5 Plate - DYC1590-5 from R&D Systems Category ELISA Kit

Human GSK3b ELISA Kit - abx151754 from Abbexa Category ELISA Kit Sensitivity 0.258 ng/ml Range 0.625 ng/ml - 40 ng/ml

Glycogen Synthase Kinase 3 Beta (GSK3b), Human, ELISA Kit - SED317Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.258ng/mL Range 0.625-40ng/mL

Glycogen Synthase Kinase 3 Beta, Human, ELISA Kit - E01G0265 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Glycogen synthase kinase-3 beta (GSK3B), Human, ELISA Kit - CSB-EL009963HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

Glycogen synthase kinase-3 beta, GSK3B, Human, ELISA Kit - E2298h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

GSK-3 Beta (Phospho), Human, ELISA - IB09637 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

GSK-3 Beta (Total), Human, ELISA - IB09611 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Glycogen Synthase Kinase 3 Beta, GSK3b, Human, ELISA Kit - E-EL-H2000 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Glycogen Synthase Kinase 3 Beta, GSK3b, Rabbit, ELISA Kit - E-EL-RB1261 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

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