GSK3B

Gene Symbol	GSK3B
Entrez Gene	2932
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	glycogen synthase kinase 3 beta
Other Description	GSK-3 beta|GSK3beta isoform|glycogen synthase kinase-3 beta|serine/threonine-protein kinase GSK3B
Swissprots	Q9UL47 D3DN89 Q9BWH3 P49841
Accessions	AAC69340 AAD48517 CBX51856 CBX51857 CBX51858 CBX51859 EAW79533 EAW79534 EAW79535 EAW79536 P49841 AB451356 BAG70170 AK290897 BAF83586 AY123976 AAM88578 BC000251 AAH00251 BC012760 AAH12760 BX640779 CA312249 CR536510 CAG38748 DA477189 DQ892501 ABM83427 DQ895714 ABM86640 EU302497 ABX89591 L33801 AAA66475 XM_006713610 XP_006713673 XM_006713611 XP_006713674 NM_001146156 NP_001139628 NM_002093 NP_002084
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.
Tissue Specificity	Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain. {ECO:0000269|PubMed:21029237}.
Top Pathways	Insulin signaling pathway, Cell cycle, Basal cell carcinoma, PI3K-Akt signaling pathway, B cell receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GSK3B-Over-expression-Lysate - LY10312a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GSK3B overexpression lysate - LY419542 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GSK-3 beta Overexpression Lysate (Native) - NBL1-11362 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GSK-3β (h): 293T Lysate - sc-176265 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Human GSK3B Insect Cell Lysate (WB positive control) - 10044-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

GSK-3 beta Overexpression Lysate (Denatured) - H00002932-T05 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human GSK3B Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174919 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

GSK3B-knockout Cell lysate - LC810097 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human GSK3B Knockdown Stable Cell Line - CSC-DC006702 from Creative biogene Category Cell Line Species Human

Human GSK3B Knockout Cell Line-HeLa - CSC-RT0753 from Creative biogene Category Cell Line Species Human

GSK3B KO Cell Lysate-HeLa - CLKO-0257 from Creative biogene Category Cell Lysate

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