HDAC4

Gene Symbol	HDAC4
Entrez Gene	9759
Alt Symbol	AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 4
Other Description	histone deacetylase A
Swissprots	Q86YH7 Q9UND6 F5GX36 P56524 E9PGB9
Accessions	AAX93070 AAX93254 EAW71165 EAW71166 P56524 AB006626 BAA22957 AF070607 AF132607 AAD29046 AI199675 AI654062 AK302719 BAH13789 AK303368 BAH13951 AK303467 BAH13968 AK303617 BAH13999 AK308791 AK310488 AK310603 AK311582 BC039904 AAH39904 BQ576173 XM_006712877 XP_006712940 XM_006712878 XP_006712941 XM_006712879 XP_006712942 XM_006712880 XP_006712943 XM_011512217 XP_011510519 XM_011512218 XP_011510520 XM_011512219 XP_011510521 XM_011512220 XP_011510522 XM_011512221 XP_011510523 XM_011512222 XP_011510524 XM_011512223 XP_011510525 XM_011512224 XP_011510526 XM_011512225 XP_011510527 XM_011512226 XP_011510528 XM_011512227 XP_011510529 XM_011512228 XP_011510530 XM_011512229 XP_011510531 XM_011512230 XP_011510532 NM_006037 NP_006028
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
Tissue Specificity	Ubiquitous.
Top Pathways	Viral carcinogenesis, Epstein-Barr virus infection, Alcoholism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat HDAC4 ELISA Kit (Cell-Based ELISA) - LS-F2040 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-HDAC4 (Ser632) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1523 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse HDAC4 ELISA Kit (Sandwich ELISA) - LS-F8856 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.129 ng/ml Range 0.313-20 ng/ml

Human HDAC4 ELISA Kit (Sandwich ELISA) - LS-F9398 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.55 ng/ml Range 0.313-20 ng/ml

Human Histone Deacetylase 4 ELISA Kit - abx151817 from Abbexa Category ELISA Kit Sensitivity 0.55 ng/ml Range 1.563 ng/ml - 100 ng/ml

Histone deacetylase 4 (HDAC4), Human, ELISA Kit - CSB-EL010240HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Histone Deacetylase 4 (HDAC4), Human, ELISA Kit - SEE904Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.55ng/mL Range 1.56-100ng/mL

HDAC4 (Human) IP-WB Antibody Pair - H00009759-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HDAC4 Colorimetric Cell-Based ELISA Kit - CB5322 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

HDAC4 (Phospho-Ser632) Colorimetric Cell-Based ELISA Kit - CBP1569 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Histone Deacetylase 4, ELISA Kit - MBS061710 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 4, ELISA Kit - MBS075802 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 4, ELISA Kit - MBS098378 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 4, ELISA Kit - MBS083049 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 4, ELISA Kit - MBS064361 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 4, ELISA Kit - MBS080029 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

histone deacetylase 4, ELISA Kit - MBS914341 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human HDAC4 is typically less than 7.8 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

Histone Deacetylase 4, ELISA Kit - MBS058076 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone Deacetylase 4 (HDAC4), ELISA Kit - MBS2019114 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.55ng/mL. Range 1.56-100ng/mL

Histone Deacetylase 4 (HDAC4), ELISA Kit - MBS2021580 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.121ng/mL. Range 0.313-20ng/mL

ELISA Kit for Histone Deacetylase 4 (HDAC4) - SEE904Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Histone Deacetylase 4 (HDAC4) - SEE904Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Histone deacetylase 4(HDAC4) ELISA kit - CSB-EL010240HU from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml. Range 31.25 pg/ml-2000 pg/ml

ELISA Kit for Histone Deacetylase 4 (HDAC4) - SEE904Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Human Histone Deacetylase 4 (HDAC4) ELISA Kit - EKU04816 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.55 ng/mL Range 1.56-100 ng/mL

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