HDAC4

Gene Symbol	HDAC4
Entrez Gene	9759
Alt Symbol	AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 4
Other Description	histone deacetylase A
Swissprots	Q86YH7 Q9UND6 F5GX36 P56524 E9PGB9
Accessions	AAX93070 AAX93254 EAW71165 EAW71166 P56524 AB006626 BAA22957 AF070607 AF132607 AAD29046 AI199675 AI654062 AK302719 BAH13789 AK303368 BAH13951 AK303467 BAH13968 AK303617 BAH13999 AK308791 AK310488 AK310603 AK311582 BC039904 AAH39904 BQ576173 XM_006712877 XP_006712940 XM_006712878 XP_006712941 XM_006712879 XP_006712942 XM_006712880 XP_006712943 XM_011512217 XP_011510519 XM_011512218 XP_011510520 XM_011512219 XP_011510521 XM_011512220 XP_011510522 XM_011512221 XP_011510523 XM_011512222 XP_011510524 XM_011512223 XP_011510525 XM_011512224 XP_011510526 XM_011512225 XP_011510527 XM_011512226 XP_011510528 XM_011512227 XP_011510529 XM_011512228 XP_011510530 XM_011512229 XP_011510531 XM_011512230 XP_011510532 NM_006037 NP_006028
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
Tissue Specificity	Ubiquitous.
Top Pathways	Viral carcinogenesis, Epstein-Barr virus infection, Alcoholism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HDAC4 protein fragment - ab104029 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

HDAC4 peptide - ab53331 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human HDAC4 peptide - ab41767 from Abcam Category Peptide Species Human

Human HDAC4 protein fragment - ab188824 from Abcam Category Protein Source Wheat germ Species Human

HDAC4 Antibody Blocking Peptide - LS-E700 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC4 Antibody Blocking Peptide - LS-E2644 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC4 Antibody Blocking Peptide - LS-E12120 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC4 Antibody Blocking Peptide - LS-E16042 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Histone Deacetylase 4/HDAC4 Protein - H00009759-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Histone Deacetylase 4/HDAC4 Protein - H00009759-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Histone Deacetylase 4/HDAC4 Peptide - P0213 from Novus Biologicals Category Peptide Species Human

HDAC4-Antibody-C-term-Blocking-Peptide - BP1104a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC4-Antibody-C-term-Blocking-peptide - BP13715b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC4 Protein Lysate (APL10197) - APL10197 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

HDAC4 Protein Lysate (APL10198) - APL10198 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Recombinant human Histone deacetylase 4 (OPCA01148) - OPCA01148 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human HD 4 protein - orb139008 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human HDAC4 protein - orb246707 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

HDAC 4 Blocking Peptide - 33R-10519 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

HDAC4 Blocking Peptide - 33R-10829 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

HDAC4 - H00009759-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

HDAC4 - H00009759-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HDAC4 - H00009759-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HDAC4 - H00009759-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HDAC4 control peptide - AP00273CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

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