| Gene Symbol | AGRP |
|---|---|
| Entrez Gene | 181 |
| Alt Symbol | AGRT, ART, ASIP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | agouti related neuropeptide |
| Other Description | agouti related protein homolog|agouti-related protein |
| Swissprots | Q2TBD9 O15459 O00253 |
| Accessions | AAK96256 AAL09457 ABC88473 DAA06531 EAW83137 O00253 BC110443 AAI10444 U88063 AAB52240 U89485 AAB68621 XM_011522927 XP_011521229 NM_001138 NP_001129 |
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}. |
| Tissue Specificity | Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| Top Pathways | Adipocytokine signaling pathway |