AGRP

Gene Symbol	AGRP
Entrez Gene	181
Alt Symbol	AGRT, ART, ASIP2
Species	Human
Gene Type	protein-coding
Description	agouti related neuropeptide
Other Description	agouti related protein homolog|agouti-related protein
Swissprots	Q2TBD9 O15459 O00253
Accessions	AAK96256 AAL09457 ABC88473 DAA06531 EAW83137 O00253 BC110443 AAI10444 U88063 AAB52240 U89485 AAB68621 XM_011522927 XP_011521229 NM_001138 NP_001129
Function	Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}.
Subcellular Location	Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}.
Tissue Specificity	Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Top Pathways	Adipocytokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AGRP peptide (120-132) - ab45721 from Abcam Category Peptide Prices $285.00 Sizes 100 µg Species Human

Human AGRP full length protein - ab202619 from Abcam Category Protein Prices $429.00 Sizes 20 µg Source E. coli Species Human

Human AGRP full length protein - ab186691 from Abcam Category Protein Prices $265.00 Sizes 10 µg Source E. coli Species Human

AGRP Antibody Blocking Peptide - LS-E25861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Agouti-Related-Protein-AGRP54-82Human - SP3201b from Abgent, a WuXi AppTec company Category Protein Prices $215.00 Sizes 1 mg

Agouti-Related-Protein-AGRP54-82Human - SP3201a from Abgent, a WuXi AppTec company Category Protein Prices $125.00 Sizes 500 µg

Agouti-Related-Protein-AGRP25-51Human - SP2916b from Abgent, a WuXi AppTec company Category Protein Prices $185.00 Sizes 1 mg

Agouti-Related-Protein-AGRP25-51Human - SP2916a from Abgent, a WuXi AppTec company Category Protein Prices $125.00 Sizes 500 µg

AGRP blocking peptide - GTX89559-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Pig

Recombinant Human AgRP C-Terminal Fragment, CF - 3726-AG-100 from R&D Systems Category Protein Source E. coli-derived, Ser83-Thr132

Recombinant Human AgRP - 704-AG-002 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Ala21-Thr132 & Leu47-Thr132, both with a C-terminal 6-His tag

AGRP Protein (OPPA01048) - OPPA01048 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human AGRP protein - orb244005 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human AGRP protein - orb80700 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human AGRP (Fc Tag) protein - orb232209 from Biorbyt Category Protein Prices $238.00, $400.00 Sizes 20 μg, 100 μg Species Human

Human AGRP protein - orb245246 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

AGRP (54-82) peptide - orb71366 from Biorbyt Category Peptide Prices $604.00 Sizes 5 mg

AGRP protein (His tag) - 80R-4152 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

Artemin protein - 30R-2625 from Fitzgerald Category Protein Prices $265.00 Sizes 20 µg Source E.coli Species Human

Human Agouti Related Protein Protein - abx065197 from Abbexa Category Protein Source E.coli Species Human

AGRP Peptide - AC21-0691-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Agouti-related protein / AGRP (21-132, His-tag) - AR51838PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

Agouti-related protein / AGRP (21-132, His-tag) - AR51838PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

Agouti-related protein / AGRP - PA503X from Acris Antibodies Category Protein Prices $550.00 Sizes 100 µg Source E. coli Species Human

Agouti-Related Protein, Human Recombinant - 228-10032-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

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