AGRP

Gene Symbol AGRP
Entrez Gene 181
Alt Symbol AGRT, ART, ASIP2
Species Human
Gene Type protein-coding
Description agouti related neuropeptide
Other Description agouti related protein homolog|agouti-related protein
Swissprots Q2TBD9 O15459 O00253
Accessions AAK96256 AAL09457 ABC88473 DAA06531 EAW83137 O00253 BC110443 AAI10444 U88063 AAB52240 U89485 AAB68621 XM_011522927 XP_011521229 NM_001138 NP_001129
Function Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}.
Subcellular Location Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}.
Tissue Specificity Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Top Pathways Adipocytokine signaling pathway

Human AGRP cDNA clone(NM_001138.1) - CDFH000487 from Creative Biomart

Species Human
Accession NM_001138.1

Human AGRP ORF clone(NM_001138.1) - CDCL182632 from Creative Biomart

Species Human
Accession NM_001138.1

Human AGRP ORF Clone(NM_001138.1) - CDCL153361 from Creative Biomart

Species Human
Accession NM_001138.1

Human AGRP ORF Clone(NM_001138.1) - CDCR350875 from Creative Biomart

Species Human
Accession NM_001138.1

Human AGRP ORF Clone(NM_001138.1) - CDCR350877 from Creative Biomart

Species Human
Accession NM_001138.1

Human AGRP ORF Clone(NM_001138.1) - CDCR350878 from Creative Biomart

Species Human
Accession NM_001138.1

AGRP - CL01100H01 from Elabscience

Species Human
Accession NM_001138.1

Human AGRP ORF clone(NM_001138.1) - CDCL182632 from Creative biogene

Species Human

Human AGRP cDNA Clone(NM_001138.1) - CDFH000487 from Creative biogene

Species Human

Human Agouti Related Protein Homolog Gene - orb90688 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Human
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