AGRP

Gene Symbol AGRP
Entrez Gene 181
Alt Symbol AGRT, ART, ASIP2
Species Human
Gene Type protein-coding
Description agouti related neuropeptide
Other Description agouti related protein homolog|agouti-related protein
Swissprots Q2TBD9 O15459 O00253
Accessions AAK96256 AAL09457 ABC88473 DAA06531 EAW83137 O00253 BC110443 AAI10444 U88063 AAB52240 U89485 AAB68621 XM_011522927 XP_011521229 NM_001138 NP_001129
Function Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269|PubMed:10371151, ECO:0000269|PubMed:11145747, ECO:0000269|PubMed:15927146, ECO:0000269|PubMed:17041250, ECO:0000269|PubMed:9892020}.
Subcellular Location Secreted {ECO:0000269|PubMed:15927146}. Golgi apparatus lumen {ECO:0000269|PubMed:15927146}.
Tissue Specificity Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Top Pathways Adipocytokine signaling pathway

AGRP CRISPR/Cas9 KO Plasmid (h) - sc-402410 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP HDR Plasmid (h) - sc-402410-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP Double Nickase Plasmid (h) - sc-402410-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP Double Nickase Plasmid (h2) - sc-402410-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP CRISPR Activation Plasmid (h) - sc-402410-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP CRISPR Activation Plasmid (h2) - sc-402410-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP Lentiviral Activation Particles (h) - sc-402410-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP Lentiviral Activation Particles (h2) - sc-402410-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AGRP siRNA (h) - sc-39287 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AGRP shRNA Plasmid (h) - sc-39287-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AGRP shRNA (h) Lentiviral Particles - sc-39287-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU119191 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2959 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2959 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

AGRP siRNA (Human) - CRH0127 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AGRP - MBS8219903 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AGRP (NM_001138.1) - SHH233466 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human AGRP(NM_001138.1) - SHG046105 from Creative biogene

Category siRNA
Species Reactivities Human

Human AGRP siRNA - orb260629 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AGRP shRNA Plasmid (Human) - CHH0127 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AGRP miRNA 3'UTR clone - MiUTR1H-00244 from Creative biogene

Species Reactivities Human
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