ELAVL1

Gene Symbol	ELAVL1
Entrez Gene	1994
Alt Symbol	ELAV1, HUR, Hua, MelG
Species	Human
Gene Type	protein-coding
Description	ELAV like RNA binding protein 1
Other Description	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)|ELAV-like protein 1|Hu antigen R|embryonic lethal, abnormal vision, drosophila, homolog-like 1|hu-antigen R
Swissprots	Q9BTT1 Q53XN6 B4DVB8 Q15717
Accessions	CCA78939 EAW68949 EAW68950 Q15717 AI375368 AK022334 AK096659 AK301013 BAG62630 AL713686 AW139417 BC003376 AAH03376 BM664469 BM696191 BT009793 AAP88795 BU542524 BX647856 EU176230 ABW03681 EU176535 ABW03336 U38175 AAB41913 W37464 XM_011527777 XP_011526079 NM_001419 NP_001410
Function	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. {ECO:0000269|PubMed:19029303}.
Subcellular Location	Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2.
Tissue Specificity	Ubiquitous.
Top Pathways	AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HuR / ELAVL1 full length protein - ab152360 from Abcam Category Protein Source Wheat germ Species Human

Human HuR / ELAVL1 peptide - ab28843 from Abcam Category Peptide

Human HuR / ELAVL1 protein fragment - ab152361 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human HuR/ELAVL1 Protein - H00001994-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human HuR/ELAVL1 Protein - H00001994-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ELAVL1 peptide - orb217244 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Sheep

HUR Blocking Peptide - abx062575 from Abbexa Category Peptide Species Human, Bovine, Pig, Sheep

ELAVL1 / HUR - H00001994-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

ELAVL1 / HUR - H00001994-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ELAVL1 / HUR - H00001994-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HuR fusion protein - Ag2249 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant ELAV Like Protein 1 (ELAVL1) - RPJ780Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

HUR Blocking Peptide - CBP1381 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Bovine, Pig, Sheep

ELAVL1 Peptide - BS60419P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human ELAV-like protein 1(ELAVL1) - CSB-YP618993HU CSB-EP618993HU CSB-BP618993HU CSB-MP618993HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HuR (1-280) - sc-4437 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

ELAVL1 / HUR - TP301562 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HuR/ELAVL1 Protein - NBP2-38548PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ELAVL1 Peptide, Human - M34GP04849H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Hu R Protein - 230-00867-10 from RayBiotech Category Protein Source Escherichia coli (E.coli) Species Human

ELAV-like protein 1 (ELAVL1), Recombinant Protein - MBS1347066 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,705.00, $1,705.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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