ELAVL1
| Gene Symbol | ELAVL1 |
|---|---|
| Entrez Gene | 1994 |
| Alt Symbol | ELAV1, HUR, Hua, MelG |
| Species | Human |
| Gene Type | protein-coding |
| Description | ELAV like RNA binding protein 1 |
| Other Description | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)|ELAV-like protein 1|Hu antigen R|embryonic lethal, abnormal vision, drosophila, homolog-like 1|hu-antigen R |
| Swissprots | Q9BTT1 Q53XN6 B4DVB8 Q15717 |
| Accessions | CCA78939 EAW68949 EAW68950 Q15717 AI375368 AK022334 AK096659 AK301013 BAG62630 AL713686 AW139417 BC003376 AAH03376 BM664469 BM696191 BT009793 AAP88795 BU542524 BX647856 EU176230 ABW03681 EU176535 ABW03336 U38175 AAB41913 W37464 XM_011527777 XP_011526079 NM_001419 NP_001410 |
| Function | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. {ECO:0000269|PubMed:19029303}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | AMPK signaling pathway |
HuR CRISPR/Cas9 KO Plasmid (h) - sc-400141 from Santa Cruz Biotechnology
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HuR HDR Plasmid (h) - sc-400141-HDR from Santa Cruz Biotechnology
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HuR Double Nickase Plasmid (h) - sc-400141-NIC from Santa Cruz Biotechnology
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HuR Double Nickase Plasmid (h2) - sc-400141-NIC-2 from Santa Cruz Biotechnology
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HuR CRISPR Activation Plasmid (h) - sc-400141-ACT from Santa Cruz Biotechnology
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HuR CRISPR Activation Plasmid (h2) - sc-400141-ACT-2 from Santa Cruz Biotechnology
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HuR Lentiviral Activation Particles (h) - sc-400141-LAC from Santa Cruz Biotechnology
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HuR Lentiviral Activation Particles (h2) - sc-400141-LAC-2 from Santa Cruz Biotechnology
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HuR siRNA (h) - sc-35619 from Santa Cruz Biotechnology
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HuR shRNA Plasmid (h) - sc-35619-SH from Santa Cruz Biotechnology
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HuR shRNA (h) Lentiviral Particles - sc-35619-V from Santa Cruz Biotechnology
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HuR/ELAVL1 RNAi - H00001994-R01 from Novus Biologicals
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MISSION® esiRNA - EHU063491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1985 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1985 from Sigma-Aldrich
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ELAVL1 siRNA (Human) - CRH1378 from Cohesion Biosciences
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ELAVL1 - MBS8238266 from MyBioSource
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shRNA set against Human ELAVL1 (NM_001419.2) - SHH284949 from Creative biogene
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shRNA set against Human ELAVL1(NM_001419.2) - SHH030779 from Creative biogene
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Human ELAVL1 siRNA - orb261880 from Biorbyt
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ELAVL1 shRNA Plasmid (Human) - CHH1378 from Cohesion Biosciences
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ELAVL1 miRNA 3'UTR clone - MiUTR1H-03186 from Creative biogene
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