| Gene Symbol |
LAS1L
|
| Entrez Gene |
81887
|
| Alt Symbol |
Las1-like, dJ475B7.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LAS1-like (S. cerevisiae)
|
| Other Description |
protein LAS1 homolog|ribosomal biogenesis protein LAS1L
|
| Swissprots |
A9X410 Q5JXQ0 Q8TEN5 Q9H9V5 Q9Y4W2
|
| Accessions |
EAX05401 EAX05402 EAX05403 EAX05404 Q9Y4W2 AF116730 AAO15306 AK022587 BAB14114 AK054695 AK054817 BAG51428 AK074087 BAB84913 AK097383 BAG53459 AK125760 BAG54243 AK127207 AK225059 AK295591 BAH12117 BC014545 AAH14545 BC018610 AAH18610 BC019302 AAH19302 DA619280 DQ323624 ABD39127 DQ323625 ABD39128 DQ323626 ABD39129 XM_005262301 XP_005262358 XM_005262304 XP_005262361 XM_005262305 XP_005262362 XM_005262306 XP_005262363 XM_005262307 XP_005262364 XM_011531045 XP_011529347 XM_011531046 XP_011529348 XR_244504 XR_430522 XR_938411 XR_938412 NM_001170649 NP_001164120 NM_001170650 NP_001164121 NM_031206 NP_112483
|
| Function |
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22872859}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20647540}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250}.
|