LAS1L

Gene Symbol LAS1L
Entrez Gene 81887
Alt Symbol Las1-like, dJ475B7.2
Species Human
Gene Type protein-coding
Description LAS1-like (S. cerevisiae)
Other Description protein LAS1 homolog|ribosomal biogenesis protein LAS1L
Swissprots A9X410 Q5JXQ0 Q8TEN5 Q9H9V5 Q9Y4W2
Accessions EAX05401 EAX05402 EAX05403 EAX05404 Q9Y4W2 AF116730 AAO15306 AK022587 BAB14114 AK054695 AK054817 BAG51428 AK074087 BAB84913 AK097383 BAG53459 AK125760 BAG54243 AK127207 AK225059 AK295591 BAH12117 BC014545 AAH14545 BC018610 AAH18610 BC019302 AAH19302 DA619280 DQ323624 ABD39127 DQ323625 ABD39128 DQ323626 ABD39129 XM_005262301 XP_005262358 XM_005262304 XP_005262361 XM_005262305 XP_005262362 XM_005262306 XP_005262363 XM_005262307 XP_005262364 XM_011531045 XP_011529347 XM_011531046 XP_011529348 XR_244504 XR_430522 XR_938411 XR_938412 NM_001170649 NP_001164120 NM_001170650 NP_001164121 NM_031206 NP_112483
Function Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269|PubMed:20647540, ECO:0000269|PubMed:22872859}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20647540}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250}.

LAS1L CRISPR/Cas9 KO Plasmid (h) - sc-407239 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L HDR Plasmid (h) - sc-407239-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L Double Nickase Plasmid (h) - sc-407239-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L Double Nickase Plasmid (h2) - sc-407239-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L CRISPR Activation Plasmid (h) - sc-407239-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L CRISPR Activation Plasmid (h2) - sc-407239-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L Lentiviral Activation Particles (h) - sc-407239-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L Lentiviral Activation Particles (h2) - sc-407239-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAS1L siRNA (h) - sc-91324 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LAS1L shRNA Plasmid (h) - sc-91324-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LAS1L shRNA (h) Lentiviral Particles - sc-91324-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU133001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11558 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11558 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00907 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00907

LAS1L siRNA (Human) - CRJ3077 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LAS1L (NM_031206.4) - SHH328587 from Creative biogene

Category siRNA
Species Reactivities Human

Human LAS1L siRNA - orb273578 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LAS1L shRNA Plasmid (Human) - CHJ3077 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LAS1L miRNA 3'UTR clone - MiUTR3H-15293 from Creative biogene

Species Reactivities Human
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