CLNS1A

Gene Symbol	CLNS1A
Entrez Gene	1207
Alt Symbol	CLCI, CLNS1B, ICln
Species	Human
Gene Type	protein-coding
Description	chloride channel, nucleotide-sensitive, 1A
Other Description	chloride channel regulatory protein|chloride channel, nucleotide sensitive 1A|chloride conductance regulatory protein ICln|chloride ion current inducer protein|i(Cln)|methylosome subunit pICln|reticulocyte pICln|reticulocyte protein ICln
Swissprots	P54105 Q9NRD3 B2RCS9 Q9NRD2 Q0VDK6
Accessions	AAF76858 AAF76859 AAF76861 EAW75032 P54105 AA757599 AF005422 AAB61444 AF026003 AAB88806 AK315259 BAG37676 BC119634 AAI19635 BC119635 AAI19636 BT019907 AAV38710 DA004269 U17899 AAC50111 U53454 AAB03316 X91788 CAA62902 NM_001293 NP_001284
Function	Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CLNS1A overexpression lysate - LY420002 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CLNS1A 293 Cell Lysate - 409365 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CLNS1A Overexpression Lysate (Native) - NBP2-08217 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CLNS1A Over-expression Lysate Product - GWB-B1D36C from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human CLNS1A Knockdown Stable Cell Line - CSC-DC003304 from Creative biogene Category Cell Line Species Human

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