CLNS1A

Gene Symbol	CLNS1A
Entrez Gene	1207
Alt Symbol	CLCI, CLNS1B, ICln
Species	Human
Gene Type	protein-coding
Description	chloride channel, nucleotide-sensitive, 1A
Other Description	chloride channel regulatory protein|chloride channel, nucleotide sensitive 1A|chloride conductance regulatory protein ICln|chloride ion current inducer protein|i(Cln)|methylosome subunit pICln|reticulocyte pICln|reticulocyte protein ICln
Swissprots	P54105 Q9NRD3 B2RCS9 Q9NRD2 Q0VDK6
Accessions	AAF76858 AAF76859 AAF76861 EAW75032 P54105 AA757599 AF005422 AAB61444 AF026003 AAB88806 AK315259 BAG37676 BC119634 AAI19635 BC119635 AAI19636 BT019907 AAV38710 DA004269 U17899 AAC50111 U53454 AAB03316 X91788 CAA62902 NM_001293 NP_001284
Function	Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLNS1A full length protein - ab132554 from Abcam Category Protein Source Wheat germ Species Human

Human CLNS1A full length protein - ab137159 from Abcam Category Protein Source E. coli Species Human

CLNS1A Antibody Blocking Peptide - LS-E8256 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLNS1A Antibody Blocking Peptide - LS-E8257 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLNS1A Antibody Blocking Peptide - LS-E18636 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLNS1A Recombinant Protein - H00001207-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CLNS1A Protein - NBP2-22777 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CLNS1A-Antibody-Center-Blocking-Peptide - BP6520c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLNS1A-Antibody-C-term-Blocking-Peptide - BP6520b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CLNS1A protein - orb168129 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E. coli Species Human

Clns1a Blocking Peptide - 33R-1337 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CLNS1A protein (His tag) - 80R-2577 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

CLNS1A Blocking Peptide - abx062439 from Abbexa Category Peptide Species Human, Dog, Rabbit

CLNS1A (1-237, His-tag) - AR50623PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CLNS1A (1-237, His-tag) - AR50623PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CLNS1A - H00001207-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLNS1A - H00001207-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLNS1A, 1-237aa, Human, His tag, E.coli - 01-P1799 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CLNS1A fusion protein - Ag22923 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PGEX-4T Species Human

CLNS1A Human - PRPS-1284 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human CLNS1A, His-tagged - CLNS1A-27276TH from Creative Biomart Category Protein Source E. coli

Recombinant Human chloride channel, nucleotide-sensitive, 1A, His-tagged - CLNS1A-360H from Creative Biomart Category Protein Source E.coli Species Human

CLNS1A Blocking Peptide - CBP1245 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Dog, Rabbit

Recombinant Human Methylosome subunit pICln(CLNS1A) - CSB-YP005572HU CSB-EP005572HU CSB-BP005572HU CSB-MP005572HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CLNS1A, 1-237aa, Human, His tag, E.coli - ATGP1799 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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