CLNS1A

Gene Symbol CLNS1A
Entrez Gene 1207
Alt Symbol CLCI, CLNS1B, ICln
Species Human
Gene Type protein-coding
Description chloride channel, nucleotide-sensitive, 1A
Other Description chloride channel regulatory protein|chloride channel, nucleotide sensitive 1A|chloride conductance regulatory protein ICln|chloride ion current inducer protein|i(Cln)|methylosome subunit pICln|reticulocyte pICln|reticulocyte protein ICln
Swissprots P54105 Q9NRD3 B2RCS9 Q9NRD2 Q0VDK6
Accessions AAF76858 AAF76859 AAF76861 EAW75032 P54105 AA757599 AF005422 AAB61444 AF026003 AAB88806 AK315259 BAG37676 BC119634 AAI19635 BC119635 AAI19636 BT019907 AAV38710 DA004269 U17899 AAC50111 U53454 AAB03316 X91788 CAA62902 NM_001293 NP_001284
Function Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton.
Top Pathways RNA transport

pICln CRISPR/Cas9 KO Plasmid (h) - sc-405798 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln HDR Plasmid (h) - sc-405798-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln Double Nickase Plasmid (h) - sc-405798-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln Double Nickase Plasmid (h2) - sc-405798-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln CRISPR Activation Plasmid (h) - sc-405798-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln CRISPR Activation Plasmid (h2) - sc-405798-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln Lentiviral Activation Particles (h) - sc-405798-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln Lentiviral Activation Particles (h2) - sc-405798-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pICln siRNA (h) - sc-42594 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

pICln shRNA Plasmid (h) - sc-42594-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

pICln shRNA (h) Lentiviral Particles - sc-42594-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLNS1A RNAi - H00001207-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU147241 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6252 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6252 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLNS1A siRNA (Human) - CRH0860 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLNS1A - MBS8228797 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLNS1A (NM_001293.2) - SHH265541 from Creative biogene

Category siRNA
Species Reactivities Human

Human CLNS1A siRNA - orb261362 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLNS1A shRNA Plasmid (Human) - CHH0860 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLNS1A miRNA 3'UTR clone - MiUTR3H-04715 from Creative biogene

Species Reactivities Human
Search more