Gapdh

Gene Symbol Gapdh
Entrez Gene 24383
Alt Symbol BARS-38, Gapd
Species Rat
Gene Type protein-coding
Description glyceraldehyde-3-phosphate dehydrogenase
Other Description 38 kDa BFA-dependent ADP-ribosylation substrate|peptidyl-cysteine S-nitrosylase GAPDH
Swissprots Q9QWU4 P09328 Q5M916 P04797
Accessions EDM01863 P04797 AB017801 BAB11748 BC059110 AAH59110 BC087743 AAH87743 DQ403053 ABD77186 M11561 AAA41795 M17701 AAA41193 M29341 AAA40814 U75401 AAB19105 X02231 CAA26150 NM_017008 NP_058704
Function Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in infl
Subcellular Location Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus. Note=Translocates to the nucleus following S- nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Tissue Specificity High levels in skeletal muscle and heart, low levels in liver, brain, and kidney. {ECO:0000269|PubMed:6548307}.
Top Pathways Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism

GAPDH Control Peptide - AP10096CP-N from Acris Antibodies

Category Peptide
Prices $235.00
Sizes 250 µg

Recombinant Rat Glyceraldehyde-3-phosphate dehydrogenase(Gapdh) - CSB-YP009232RA CSB-EP009232RA CSB-BP009232RA CSB-MP009232RA from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Rat

GAPDH, Peptide - MBS443080 from MyBioSource

Category Peptide
Prices $125.00
Sizes 100 µg

Recombinant Rat GAPDH Protein - GAPDH-2476R from Creative Biomart

Category Protein
Source Mammalian Cells
Species Rat

Glyceraldehyde-3-phosphate dehydrogenase (Gapdh), Recombinant Protein - MBS1199474 from MyBioSource

Category Protein
Prices $1,095.00, $1,095.00, $1,325.00, $1,325.00, $1,725.00, $1,725.00, $2,185.00, $2,185.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Rat
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