| Gene Symbol |
Gapdh
|
| Entrez Gene |
24383
|
| Alt Symbol |
BARS-38, Gapd
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glyceraldehyde-3-phosphate dehydrogenase
|
| Other Description |
38 kDa BFA-dependent ADP-ribosylation substrate|peptidyl-cysteine S-nitrosylase GAPDH
|
| Swissprots |
Q9QWU4 P09328 Q5M916 P04797
|
| Accessions |
EDM01863 P04797 AB017801 BAB11748 BC059110 AAH59110 BC087743 AAH87743 DQ403053 ABD77186 M11561 AAA41795 M17701 AAA41193 M29341 AAA40814 U75401 AAB19105 X02231 CAA26150 NM_017008 NP_058704
|
| Function |
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in infl
|
| Subcellular Location |
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus. Note=Translocates to the nucleus following S- nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
|
| Tissue Specificity |
High levels in skeletal muscle and heart, low levels in liver, brain, and kidney. {ECO:0000269|PubMed:6548307}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism
|