| Gene Symbol |
Slc22a3
|
| Entrez Gene |
20519
|
| Alt Symbol |
EMT, Oct3, Orct3, Slca22a3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic cation transporter), member 3
|
| Other Description |
organic cation transporter 3|solute carrier family 22 member 3|solute carrier family 22, member 3
|
| Swissprots |
Q9R209 Q9WTW5
|
| Accessions |
AAD20238 AAM22155 CAC36405 EDL02059 Q9WTW5 AF078750 AAD20978 AF082566 AAD53007 AK143988 BAE25648 BC137661 AAI37662 BC137662 AAI37663 NM_011395 NP_035525
|
| Function |
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10966924, ECO:0000305}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus. {ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568, ECO:0000305}.
|
| Top Pathways |
Choline metabolism in cancer
|