Gene Symbol | Slc22a3 |
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Entrez Gene | 20519 |
Alt Symbol | EMT, Oct3, Orct3, Slca22a3 |
Species | Mouse |
Gene Type | protein-coding |
Description | solute carrier family 22 (organic cation transporter), member 3 |
Other Description | organic cation transporter 3|solute carrier family 22 member 3|solute carrier family 22, member 3 |
Swissprots | Q9R209 Q9WTW5 |
Accessions | AAD20238 AAM22155 CAC36405 EDL02059 Q9WTW5 AF078750 AAD20978 AF082566 AAD53007 AK143988 BAE25648 BC137661 AAI37662 BC137662 AAI37663 NM_011395 NP_035525 |
Function | Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10966924, ECO:0000305}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Highly expressed in placenta and in kidney cortex, but not in medulla. Low levels found in brain. In the kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule, but not in the glomerulus. {ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568, ECO:0000305}. |
Top Pathways | Choline metabolism in cancer |
OCT3 CRISPR/Cas9 KO Plasmid (m) - sc-422992 from Santa Cruz Biotechnology
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OCT3 HDR Plasmid (m) - sc-422992-HDR from Santa Cruz Biotechnology
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OCT3 Double Nickase Plasmid (m) - sc-422992-NIC from Santa Cruz Biotechnology
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OCT3 Double Nickase Plasmid (m2) - sc-422992-NIC-2 from Santa Cruz Biotechnology
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OCT3 CRISPR Activation Plasmid (m) - sc-422992-ACT from Santa Cruz Biotechnology
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OCT3 CRISPR Activation Plasmid (m2) - sc-422992-ACT-2 from Santa Cruz Biotechnology
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OCT3 Lentiviral Activation Particles (m) - sc-422992-LAC from Santa Cruz Biotechnology
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OCT3 Lentiviral Activation Particles (m2) - sc-422992-LAC-2 from Santa Cruz Biotechnology
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OCT3 siRNA (m) - sc-42557 from Santa Cruz Biotechnology
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OCT3 shRNA Plasmid (m) - sc-42557-SH from Santa Cruz Biotechnology
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OCT3 shRNA (m) Lentiviral Particles - sc-42557-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU021981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN41325 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41325 from Sigma-Aldrich
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SLC22A3 siRNA (Mouse) - CRM3769 from Cohesion Biosciences
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SLC22A3 - MBS8233863 from MyBioSource
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shRNA set against Mouse SLC22A3 (NM_011395.2) - SHH409188 from Creative biogene
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shRNA set against Mouse Slc22a3(NM_011395.2) - SHL001470 from Creative biogene
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Mouse SLC22A3 siRNA - orb283245 from Biorbyt
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SLC22A3 shRNA Plasmid (Mouse) - CHM3769 from Cohesion Biosciences
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SLC22A3 miRNA 3'UTR clone - MiUTR1M-10790 from Creative biogene
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