| Gene Symbol | TPP1 |
|---|---|
| Entrez Gene | 1200 |
| Alt Symbol | CLN2, GIG1, LPIC, SCAR7, TPP-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tripeptidyl peptidase I |
| Other Description | cell growth-inhibiting gene 1 protein|growth-inhibiting protein 1|lysosomal pepstatin insensitive protease|tripeptidyl aminopeptidase|tripeptidyl-peptidase 1 |
| Swissprots | Q71JP6 Q5JAK6 Q96C37 O14773 Q6UX56 Q53HT1 |
| Accessions | AAC98480 CAH05560 EAW68685 EAW68686 O14773 AF017456 AAB80725 AI023962 AK222499 BAD96219 AK222538 BAD96258 AK293518 BAG57000 AK293741 BAG57164 AK295801 BAG58620 AK299703 BAG61604 AK300998 BAG62617 AK303323 BAG64389 AK312388 BAG35305 AY268890 AAQ72732 AY358502 AAQ88866 BC014863 AAH14863 BP279860 BP287220 DQ891682 ABM82608 DQ894867 ABM85793 NM_000391 NP_000382 |
| Function | Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250}. |
| Subcellular Location | Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. |
| Top Pathways | Lysosome |