TPP1

Gene Symbol	TPP1
Entrez Gene	1200
Alt Symbol	CLN2, GIG1, LPIC, SCAR7, TPP-1
Species	Human
Gene Type	protein-coding
Description	tripeptidyl peptidase I
Other Description	cell growth-inhibiting gene 1 protein|growth-inhibiting protein 1|lysosomal pepstatin insensitive protease|tripeptidyl aminopeptidase|tripeptidyl-peptidase 1
Swissprots	Q71JP6 Q5JAK6 Q96C37 O14773 Q6UX56 Q53HT1
Accessions	AAC98480 CAH05560 EAW68685 EAW68686 O14773 AF017456 AAB80725 AI023962 AK222499 BAD96219 AK222538 BAD96258 AK293518 BAG57000 AK293741 BAG57164 AK295801 BAG58620 AK299703 BAG61604 AK300998 BAG62617 AK303323 BAG64389 AK312388 BAG35305 AY268890 AAQ72732 AY358502 AAQ88866 BC014863 AAH14863 BP279860 BP287220 DQ891682 ABM82608 DQ894867 ABM85793 NM_000391 NP_000382
Function	Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250}.
Subcellular Location	Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity	Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CLN2 CRISPR/Cas9 KO Plasmid (h) - sc-405204 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 HDR Plasmid (h) - sc-405204-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 Double Nickase Plasmid (h) - sc-405204-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 Double Nickase Plasmid (h2) - sc-405204-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 CRISPR Activation Plasmid (h) - sc-405204-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 CRISPR Activation Plasmid (h2) - sc-405204-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 Lentiviral Activation Particles (h) - sc-405204-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 Lentiviral Activation Particles (h2) - sc-405204-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 siRNA (h) - sc-45578 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CLN2 shRNA Plasmid (h) - sc-45578-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CLN2 shRNA (h) Lentiviral Particles - sc-45578-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU022361 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN21873 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21873 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TPP1 siRNA (Human) - CRH0857 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Tripeptidyl-Peptidase I/TPP1 RNAi - H00001200-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TPP1 - MBS8221209 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CLN2 CRISPR/Cas9 KO Plasmid (h2) - sc-405204-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLN2 HDR Plasmid (h2) - sc-405204-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human TPP1 (NM_000391.3) - SHH433384 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TPP1(NM_000391.3) - SHL090070 from Creative biogene Category siRNA Species Reactivities Human

Human TPP1 siRNA - orb261359 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TPP1 shRNA Plasmid (Human) - CHH0857 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TPP1 miRNA 3'UTR clone - MiUTR1H-10677 from Creative biogene Species Reactivities Human

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