| Gene Symbol | RAB35 |
|---|---|
| Entrez Gene | 11021 |
| Alt Symbol | H-ray, RAB1C, RAY |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB35, member RAS oncogene family |
| Other Description | GTP-binding protein RAY|ras-related protein Rab-35|ras-related protein rab-1c (GTP-binding protein ray) |
| Swissprots | B2R6E0 Q15286 B4E390 |
| Accessions | AAC83182 CAJ34551 CCD32725 EAW98163 EAW98164 Q15286 AF498960 AAM21108 AI042456 AK001309 AK125543 AK298391 BAG60626 AK300127 BAG61918 AK304620 BAG65402 AK312538 BAG35437 BC015931 AAH15931 BC017753 BM467132 BP303346 BQ233709 BT020024 AAV38827 CR536486 CAG38725 CR541683 CAG46484 DC349830 DC370610 DC408044 DQ890586 ABM92203 DQ890603 ABM92220 DQ893750 ABM84676 X79781 CAA56177 XM_011537779 XP_011536081 NM_001167606 NP_001161078 NM_006861 NP_006852 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, clathrin- coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Note=Present on sorting endosomes and recycling endosome tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified in stage I to stage IV melanosomes. |