KDR

Gene Symbol KDR
Entrez Gene 3791
Alt Symbol CD309, FLK1, VEGFR, VEGFR2
Species Human
Gene Type protein-coding
Description kinase insert domain receptor
Other Description fetal liver kinase 1|fetal liver kinase-1|kinase insert domain receptor (a type III receptor tyrosine kinase)|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2
Swissprots C5IFA0 P35968 Q14178 A2RRS0 O60723 B5A925
Accessions CAA61916 EAX05462 EAX05463 EAX05464 P35968 AB209901 BAD93138 AF035121 AAB88005 AF063658 AAC16450 AK293668 BAG57114 BC131822 AAI31823 BP280621 EU826563 ACF47599 FJ899739 ACR78514 L04947 AAA59459 X61656 CAA43837 NM_002253 NP_002244
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p
Subcellular Location Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity Detected in cornea (at protein level). Widely expressed. {ECO:0000269|PubMed:19668192}.
Top Pathways Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

VEGF Receptor 2 (D5B1) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 12687 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5B1
Flow cytometric analysis of HUVE cells using VEGF Receptor 2 (D5B1) Rabbit mAb (Alexa Fluor ® 488 Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (Alexa Fluor ® 488 Conjugate) #2975 (red).

VEGF Receptor 2 (D5B1) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 12658 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5B1
Flow cytometric analysis of HUVE cells using VEGF Receptor 2 (D5B1) Rabbit mAb (Alexa Fluor ® 647 Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (Alexa Fluor ® 647 Conjugate) #2985 (red).

VEGF Receptor 2 (D5B1) Rabbit mAb (Pacific Blue™ Conjugate) - 12772 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5B1
Flow cytometric analysis of HeLa (blue) and HUVE (green) cells using VEGF Receptor 2 (D5B1) Rabbit mAb (Pacific Blue™ Conjugate).

VEGF Receptor 2 (D5B1) Rabbit mAb (Alexa Fluor ® 555 Conjugate) - 12872 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5B1
Confocal immunofluorescent analysis of rat pancreas using VEGF Receptor 2 (D5B1) Rabbit mAb (Alexa Fluor® 555 Conjugate) (red) and β-Catenin (L54E2) Mouse mAb (IF Preferred) #2677 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

VEGF Receptor 2 (D5B1) Rabbit mAb (PE Conjugate) - 12634 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5B1
Flow cytometric analysis of HeLa cells (blue) and HUVEC cells (green) using VEGF Receptor 2 (D5B1) Rabbit mAb (PE Conjugate).

VEGF Receptor 2 (55B11) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 3628 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 55B11

VEGF Receptor 2 (55B11) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 3627 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 55B11

VEGF Receptor 2 (D5B1) Rabbit mAb - 9698 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5B1
Western blot analysis of extracts from HUVE cells, HeLa cells and mouse heart using VEGF Receptor 2 (D5B1) Rabbit mAb for VEGFR2 expression (upper) and β-Actin (D6A8) Rabbit mAb (#8457) for loading control. (The 80 kDa bands represent partial degradation product).

VEGF Receptor 2 Antibody - 2472 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PAE cells overexpressing VEGF receptor 1 and chimeric VEGF receptor 2 respectively, using VEGF Receptor 2 Antibody. PAE/CKR cells overexpress chimeric receptors containing human CSF-1 extracellular binding domain/mouse VEGF receptor 2 intracellular domains.(7).

VEGF Receptor 2 (55B11) Rabbit mAb - 2479 from Cell Signaling Technology

Prices $246.00, $637.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 55B11
Western blot analysis of extracts from various cell lines and primary cell cultures, using VEGF Receptor 2 (55B11) Rabbit mAb. PAE/CKR cells overexpress chimeric receptors containing human CSF-1 extracellular binding domain/mouse VEGF receptor 2 intracellular domains (Rahimi, N. et al. [2000] J. Biol. Chem. 275, 16986-16992). PAE/VEGFR1 cells overexpress human VEGF receptor 1.

Phospho-VEGF Receptor 2 (Tyr951) Antibody - 2471 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of CKR/PAE cells expressing chimeric receptors containing human CSF-1 extracellular binding domain/mouse VEGFR-2 intracellular domains (Rahimi, N. et al. [2000] J. Biol. Chem. 275, 16986-16992), using Phospho-VEGF Receptor 2 (Tyr951) Antibody (upper) or VEGF receptor 2 antibody (lower).

Phospho-VEGF Receptor 2 (Tyr1175) (D5B11) Rabbit mAb - 3770 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5B11
Western blot analysis of extracts from HUVEC, untreated or stimulated with VEGF #9943, using Phospho-VEGF Receptor 2 (Tyr1175) (D5B11) Rabbit mAb (upper) and VEGF Receptor 2 (55B11) Rabbit mAb (lower) #2479.

Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb - 2478 from Cell Signaling Technology

Prices $109.00, $307.00, $719.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 19A10
Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb specifically binds to phosphorylated VEGFR2, but not other phosphorylated tyrosine kinases. Western blot analysis of extracts from cells expressing different activated tyrosine kinase proteins, using Phospho-VEGF Receptor-2 (Tyr1175) (19A10) Rabbit mAb (upper) and Phospho-Tyrosine mAb (P-Tyr-100) #9411 (lower). CKR/PAE cells (lanes 12 and 13) express chimeric receptors containing human CSF-1 extracellular binding domain/mouse VEGF receptor-2 intracellular domain (7). CSF-1 stimulates phosphorylation of Tyr1175 of intracellular VEGF receptor-2 domain (lane 12), which was specifically detected by Phospho-VEGF Receptor-2 (Tyr1175) (19A10) Rabbit mAb.

Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb - 2477 from Cell Signaling Technology

Prices $307.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 11A3
Western blot analysis of recombinant human GST-VEGF Receptor 2 (Val789-Val1356), untreated or λ phosphatase-treated, using Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb (upper) and VEGF Receptor 2 Antibody #2472 (lower).

Phospho-VEGF Receptor 2 (Tyr951) (15D2) Rabbit mAb - 4991 from Cell Signaling Technology

Prices $109.00, $307.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 15D2
Western blot analysis of recombinant human GST-VEGF Receptor 2 (Val789-Val1356), untreated or λ phosphatase-treated, using Phospho-VEGF Receptor 2 (Tyr951) (15D2) Rabbit mAb (upper) and VEGF Receptor 2 Antibody # 2472 (lower).

Phospho-VEGF Receptor 2 (Tyr951) (7H11) Mouse mAb - 2476 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 7H11
Western blot analysis of extracts from CKR/PAE cells expressing chimeric receptors containing human CSF-1 receptor extracellular binding domain/mouse VEGF receptor 2 intracellular domian (Rahimi, N. et al. (2000) J. Biol. Chem. 275, 16986-16992), using Phospho-VEGF Receptor 2 (Tyr951) (7H11) Mouse mAb.

Phospho-VEGF Receptor 2 (Tyr996) Antibody - 2474 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from CKR/PAE cells expressing chimeric receptors containing human CSF-1 extracellular binding domain/mouse VEGF receptor 2 intracellular domains (Rahimi, N. et al. (2000) J. Biol. Chem. 275, 16986-16992), using Phospho-VEGF Receptor 2 (Tyr996) Antibody (upper) or VEGF receptor 2 antibody (lower).

Flk-1 (A-3) - sc-6251 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Flk-1 (A-3): sc-6251. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue showing membrane staining.

Flk-1 (D-8) - sc-393163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Flk-1 (D-8): sc-393163. Western blot analysis of Flk-1 expression in non-transfected: sc-117752 (A) and mouse Flk-1 transfected: sc-120289 (B) 293T whole cell lysates.

Flk-1 (F-10) - sc-393179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Flk-1 (F-10): sc-393179. Western blot analysis of Flk-1 expression in non-transfected: sc-117752 (A) and mouse Flk-1 transfected: sc-120289 (B) 293T whole cell lysates.

Flk-1 (C-1158) - sc-504 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Flk-1 (C-1158): sc-504. Western blot analysis of Flk-1 expression in c4 whole cell lysate.

Flk-1 (N-931) - sc-505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Flk-1 (N-931): sc-505. Western blot analysis of Flk-1 expression in mouse liver (A) and rat liver (B) tissue extracts.

Flk-1 (Q-20) - sc-19530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Flk-1 (Q-20): sc-19530. Western blot analysis of Flk-1 expression in ECV304 (A) and c4 (B) whole cell lysates.

Flk-1 (S-20) - sc-48161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Flk-1 (S-20): sc-48161. Western blot analysis of Flk-1 expression in mouse liver tissue extract.

p-Flk-1 (Tyr 951) - sc-16628 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Flk-1 (Tyr 951)-R: sc-16628-R. Western blot analysis of Flk-1 phosphorylation in non-transfected: sc-117752 (A) and mouse Flk-1 transfected: sc-120289 (B) 293T whole cell lysates.
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