KDR

Gene Symbol	KDR
Entrez Gene	3791
Alt Symbol	CD309, FLK1, VEGFR, VEGFR2
Species	Human
Gene Type	protein-coding
Description	kinase insert domain receptor
Other Description	fetal liver kinase 1|fetal liver kinase-1|kinase insert domain receptor (a type III receptor tyrosine kinase)|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2
Swissprots	C5IFA0 P35968 Q14178 A2RRS0 O60723 B5A925
Accessions	CAA61916 EAX05462 EAX05463 EAX05464 P35968 AB209901 BAD93138 AF035121 AAB88005 AF063658 AAC16450 AK293668 BAG57114 BC131822 AAI31823 BP280621 EU826563 ACF47599 FJ899739 ACR78514 L04947 AAA59459 X61656 CAA43837 NM_002253 NP_002244
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p
Subcellular Location	Isoform 2: Secreted {ECO:0000305}.
Tissue Specificity	Detected in cornea (at protein level). Widely expressed. {ECO:0000269|PubMed:19668192}.
Top Pathways	Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan® Total VEGFR-2 Sandwich ELISA Kit - 7340 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total VEGFR-2 Sandwich ELISA Antibody Pair - 7825 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Phospho-VEGFR-2 (Tyr1175) Sandwich ELISA Kit - 7335 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-VEGFR-2 (Tyr1175) Sandwich ELISA Antibody Pair - 7824 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

HTScan® VEGF Receptor 2 Kinase Assay Kit - 7788 from Cell Signaling Technology Category Assay Kit

VEGF Receptor 2 Human ELISA Kit - ab100665 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 70 pg/ml Range 34.3 pg/ml - 25000 pg/ml

VEGF Receptor 2 Human SimpleStep ELISA™ Kit - ab192148 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 11.1 pg/ml Range 117 pg/ml - 7500 pg/ml

Mouse/Human/Rat KDR / VEGFR2 / FLK1 ELISA Kit (Cell-Based ELISA) - LS-F2385 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 62.5-4000 pg/ml

Mouse KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F2595 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 2 pg/ml Range 62.5-4000 pg/ml

Human KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F2572 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 4 pg/ml Range 62.5-4000 pg/ml

Human KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F4577 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.236 ng/ml Range 62.5-4000 pg/ml

Mouse KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F5757 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 0.068 ng/ml Range 62.5-4000 pg/ml

Rat KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F5828 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 62.5 pg/ml Range 62.5-4000 pg/ml

Human KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F212 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 34.3 pg/ml Range 62.5-4000 pg/ml

Human KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F653 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 62.5-4000 pg/ml

Mouse/Human/Rat Phospho-KDR / VEGFR2 / FLK1 (Tyr1059) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1235 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 62.5-4000 pg/ml

Mouse/Human/Rat Phospho-KDR / VEGFR2 / FLK1 (Tyr1175) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1647 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 62.5-4000 pg/ml

Mouse/Human/Rat Phospho-KDR / VEGFR2 / FLK1 (Tyr1214) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1648 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 62.5-4000 pg/ml

Mouse/Human Phospho-KDR / VEGFR2 / FLK1 (Tyr951) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1649 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 62.5-4000 pg/ml

Pig KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F9498 from LifeSpan Bioscience Category ELISA Kit Prices $820.00 Sizes 1 plate Sensitivity 0.62 ng/ml Range 62.5-4000 pg/ml

Human KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F9997 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.144 ng/ml Range 62.5-4000 pg/ml

Mouse KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F12946 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 62.5-4000 pg/ml

Rat KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F12945 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 62.5-4000 pg/ml

Human KDR / VEGFR2 / FLK1 ELISA Kit (Sandwich ELISA) - LS-F12944 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.78 Range 62.5-4000 pg/ml

Human VEGF R2 ELISA Kit - RAB0328 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

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