KDR
| Gene Symbol | KDR |
|---|---|
| Entrez Gene | 3791 |
| Alt Symbol | CD309, FLK1, VEGFR, VEGFR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | kinase insert domain receptor |
| Other Description | fetal liver kinase 1|fetal liver kinase-1|kinase insert domain receptor (a type III receptor tyrosine kinase)|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2 |
| Swissprots | C5IFA0 P35968 Q14178 A2RRS0 O60723 B5A925 |
| Accessions | CAA61916 EAX05462 EAX05463 EAX05464 P35968 AB209901 BAD93138 AF035121 AAB88005 AF063658 AAC16450 AK293668 BAG57114 BC131822 AAI31823 BP280621 EU826563 ACF47599 FJ899739 ACR78514 L04947 AAA59459 X61656 CAA43837 NM_002253 NP_002244 |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p |
| Subcellular Location | Isoform 2: Secreted {ECO:0000305}. |
| Tissue Specificity | Detected in cornea (at protein level). Widely expressed. {ECO:0000269|PubMed:19668192}. |
| Top Pathways | Cytokine-cytokine receptor interaction, VEGF signaling pathway, Focal adhesion, Endocytosis, PI3K-Akt signaling pathway |
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