APOE

Gene Symbol APOE
Entrez Gene 348
Alt Symbol AD2, APO-E, LDLCQ5, LPG
Species Human
Gene Type protein-coding
Description apolipoprotein E
Other Description apolipoprotein E3
Swissprots Q9P2S4 P02649 C0JYY5 B2RC15
Accessions AAB59397 AAD02505 AAG27089 AAL82810 ACN81314 ADK26133 AFS60672 BAA96080 CAA63051 EAW57306 P02649 AK308546 AK314898 BAG37412 AL037046 BC003557 AAH03557 BI550631 BM042032 BU848796 CA771535 DB486513 DQ892548 ABM83474 DQ895759 ABM86685 HY056112 HY074384 HY074888 K00396 AAB59546 M12529 AAB59518 X00199 CAA25017 Z70760 CAA94806 NM_000041 NP_000032 NM_001302688 NP_001289617 NM_001302689 NP_001289618 NM_001302690 NP_001289619 NM_001302691 NP_001289620
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Subcellular Location Secreted.
Tissue Specificity Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.
Top Pathways Alzheimer's disease

apoE CRISPR/Cas9 KO Plasmid (h) - sc-400860 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE HDR Plasmid (h) - sc-400860-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE Double Nickase Plasmid (h) - sc-400860-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE Double Nickase Plasmid (h2) - sc-400860-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE CRISPR Activation Plasmid (h) - sc-400860-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE CRISPR Activation Plasmid (h2) - sc-400860-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE Lentiviral Activation Particles (h) - sc-400860-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE Lentiviral Activation Particles (h2) - sc-400860-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE siRNA (h) - sc-29708 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

apoE shRNA Plasmid (h) - sc-29708-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

apoE shRNA (h) Lentiviral Particles - sc-29708-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1605 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1605 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

APOE siRNA (Human) - CRH0246 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Apolipoprotein E/ApoE RNAi - H00000348-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

APOE - MBS827742 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

apoE CRISPR/Cas9 KO Plasmid (h2) - sc-400860-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

apoE HDR Plasmid (h2) - sc-400860-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human APOE (NM_000041.2) - SHH238542 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human APOE(NM_000041.2) - SHG065827 from Creative biogene

Category siRNA
Species Reactivities Human

Human Apolipoprotein E siRNA - orb260748 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APOE shRNA Plasmid (Human) - CHH0246 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APOE miRNA 3'UTR clone - MiUTR1H-00479 from Creative biogene

Species Reactivities Human
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