BLM

Gene Symbol BLM
Entrez Gene 641
Alt Symbol BS, RECQ2, RECQL2, RECQL3
Species Human
Gene Type protein-coding
Description Bloom syndrome, RecQ helicase-like
Other Description Bloom syndrome protein|DNA helicase, RecQ-like type 2|recQ protein-like 3
Swissprots P54132 Q52M96
Accessions AAW62255 EAX02107 EAX02108 P54132 AK295194 BAH12008 AK303159 BAH13907 AK314262 BAG36927 BC034480 BC062697 BC093622 AAH93622 BC101567 AAI01568 BC107423 AAI07424 BC115028 BC115029 BC115030 AAI15031 BC115031 BC115032 AAI15033 BC143280 AAI43281 BC143288 BP363946 CD707743 DA122319 DB520927 U39817 AAA87850 XM_006720632 XP_006720695 XM_011521881 XP_011520183 XM_011521882 XP_011520184 NM_000057 NP_000048 NM_001287246 NP_001274175 NM_001287247 NP_001274176 NM_001287248 NP_001274177
Function Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). {ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:9388193}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23509288}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
Top Pathways Homologous recombination, Fanconi anemia pathway

BLM Antibody - 2742 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and Jurkat cells using BLM Antibody.

BLM (F-5) - sc-376616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BLM (F-5): sc-376616. Western blot analysis of BLM expression in K-562 nuclear extract.

BLM (C-18) - sc-7790 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BLM (C-18): sc-7790. Western blot analysis of BLM expression in K-562 nulear extract.

BLM (B-4) - sc-365753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BLM (B-4): sc-365753. Western blot analysis of BLM expression in K-562 nuclear extract.

BLM (K-20) - sc-7791 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BLM (K-20): sc-7791. Western blot analysis of BLM expression in K-562 nulear extract.

BLM (C-1) - sc-376237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BLM (C-1): sc-376237. Western blot analysis of BLM expression in K-562 nuclear extract.

BLM (H-300) - sc-14018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BLM (H-300): sc-14018. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing nuclear and cytoplasmic staining of glandular cells.

BLM (N-19) - sc-7789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BLM (N-19): sc-7789. Western blot analysis of BLM expression in K-562 nulear extract.

BLM (BFL103) - sc-13584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BLM (BFL103): sc-13584. Immunofluorescence staining of methanol-fixed K-562 cells showing nuclear localization.

BLM (4i317) - sc-70426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Blooms Syndrome Protein Blm (phospho T99) antibody - ab62206 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells using Blooms Syndrome Protein Blm (phospho T99) antibody (ab62206) at 1/500 dilution, in the presence (right) or absence (left) of immunising phosphopeptide.

Anti-Blooms Syndrome Protein Blm antibody - ab2179 from Abcam

Prices $398.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Blooms Syndrome Protein Blm antibody - ab476 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Blooms Syndrome Protein Blm antibody - ab86664 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Blooms Syndrome Protein Blm antibody (ab86664) at 1/500 dilution + 35µg of HL60 whole cell lysateSecondaryGoat anti-rabbit IgG conjugated to HRP

Anti-Blooms Syndrome Protein Blm antibody - ab135103 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Blooms Syndrome Protein Blm antibody (ab135103) at 1/1000 dilution + Mouse brain tissue lysate

Anti-Blooms Syndrome Protein Blm antibody - ab5446 from Abcam

Prices $372.00
Sizes 50 µl
Host Goat
Clonality Polyclonal

Anti-Blooms Syndrome Protein Blm antibody - ab70308 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Blooms Syndrome Protein Blm antibody - ab70309 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Blooms Syndrome Protein Blm antibody [BFL 103] (FITC) - ab187811 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone BFL 103

Anti-Blooms Syndrome Protein Blm antibody [BFL 103] (HRP) - ab187810 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone BFL 103

Anti-Blooms Syndrome Protein Blm antibody [BFL-103] - ab5409 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone BFL-103

Anti-Blooms Syndrome Protein Blm antibody - C-terminal - ab137345 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Blooms Syndrome Protein Blm antibody - C-terminal (ab137345) at 1/1000 dilutionLane 1 : NIH 3T3 whole cell lysateLane 2 : JC whole cell lysateLane 3 : BCL1 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-BLM Antibody (aa318-335) - LS-C2998 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BLM Antibody - LS-C4190 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-BLM Antibody - LS-C48692 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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