BLM

Gene Symbol	BLM
Entrez Gene	641
Alt Symbol	BS, RECQ2, RECQL2, RECQL3
Species	Human
Gene Type	protein-coding
Description	Bloom syndrome, RecQ helicase-like
Other Description	Bloom syndrome protein|DNA helicase, RecQ-like type 2|recQ protein-like 3
Swissprots	P54132 Q52M96
Accessions	AAW62255 EAX02107 EAX02108 P54132 AK295194 BAH12008 AK303159 BAH13907 AK314262 BAG36927 BC034480 BC062697 BC093622 AAH93622 BC101567 AAI01568 BC107423 AAI07424 BC115028 BC115029 BC115030 AAI15031 BC115031 BC115032 AAI15033 BC143280 AAI43281 BC143288 BP363946 CD707743 DA122319 DB520927 U39817 AAA87850 XM_006720632 XP_006720695 XM_011521881 XP_011520183 XM_011521882 XP_011520184 NM_000057 NP_000048 NM_001287246 NP_001274175 NM_001287247 NP_001274176 NM_001287248 NP_001274177
Function	Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). {ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:9388193}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:23509288}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
Top Pathways	Homologous recombination, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human Blooms Syndrome Protein Blm protein fragment - ab152235 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BLM Antibody Blocking Peptide - LS-E7617 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Blooms Syndrome Protein Blm Protein - H00000641-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BLM-Antibody-C-term-Blocking-Peptide - BP4860b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Blooms Syndrome Protein Blm Peptide - AC21-2174-P from Abcore Category Protein Prices $160.00 Sizes 100 µg

BLM - H00000641-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BLM - H00000641-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BLM Peptide - 350521 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human Bloom syndrome protein(BLM) ,partial - CSB-YP002715HU CSB-EP002715HU CSB-BP002715HU CSB-MP002715HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BLM, Peptide - MBS428419 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat

BLM, Peptide - MBS427775 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Blooms Syndrome Protein Blm Protein - NBP1-89929PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

BLM Blocking Peptide (OESA09422) - OESA09422 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

BLM-Antibody-C-term-Blocking-Peptide - BP6782b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BLM Peptide, Human - M34GP01454H from Creative Peptides Category Peptide Source Synthetic. Species Human

Bloom syndrome protein (BLM), partial, Recombinant Protein - MBS960865 from MyBioSource Category Protein Prices $925.00, $925.00, $1,145.00, $1,145.00, $1,315.00, $1,315.00, $1,780.00, $1,780.00, $1,810.00, $2,595.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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