BLM
| Gene Symbol | BLM |
|---|---|
| Entrez Gene | 641 |
| Alt Symbol | BS, RECQ2, RECQL2, RECQL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Bloom syndrome, RecQ helicase-like |
| Other Description | Bloom syndrome protein|DNA helicase, RecQ-like type 2|recQ protein-like 3 |
| Swissprots | P54132 Q52M96 |
| Accessions | AAW62255 EAX02107 EAX02108 P54132 AK295194 BAH12008 AK303159 BAH13907 AK314262 BAG36927 BC034480 BC062697 BC093622 AAH93622 BC101567 AAI01568 BC107423 AAI07424 BC115028 BC115029 BC115030 AAI15031 BC115031 BC115032 AAI15033 BC143280 AAI43281 BC143288 BP363946 CD707743 DA122319 DB520927 U39817 AAA87850 XM_006720632 XP_006720695 XM_011521881 XP_011520183 XM_011521882 XP_011520184 NM_000057 NP_000048 NM_001287246 NP_001274175 NM_001287247 NP_001274176 NM_001287248 NP_001274177 |
| Function | Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). {ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:9388193}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:23509288}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner. |
| Top Pathways | Homologous recombination, Fanconi anemia pathway |
BLM CRISPR/Cas9 KO Plasmid (h) - sc-400896 from Santa Cruz Biotechnology
|
||||||||
BLM HDR Plasmid (h) - sc-400896-HDR from Santa Cruz Biotechnology
|
||||||||
BLM Double Nickase Plasmid (h) - sc-400896-NIC from Santa Cruz Biotechnology
|
||||||||
BLM Double Nickase Plasmid (h2) - sc-400896-NIC-2 from Santa Cruz Biotechnology
|
||||||||
BLM CRISPR Activation Plasmid (h) - sc-400896-ACT from Santa Cruz Biotechnology
|
||||||||
BLM CRISPR Activation Plasmid (h2) - sc-400896-ACT-2 from Santa Cruz Biotechnology
|
||||||||
BLM Lentiviral Activation Particles (h) - sc-400896-LAC from Santa Cruz Biotechnology
|
||||||||
BLM Lentiviral Activation Particles (h2) - sc-400896-LAC-2 from Santa Cruz Biotechnology
|
||||||||
BLM siRNA (h) - sc-29808 from Santa Cruz Biotechnology
|
||||||||
BLM shRNA Plasmid (h) - sc-29808-SH from Santa Cruz Biotechnology
|
||||||||
BLM shRNA (h) Lentiviral Particles - sc-29808-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU091741 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1404 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1403 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1405 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1405 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1404 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1403 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR00772 from Sigma-Aldrich
|
||||||||
BLM siRNA (Human) - CRH0437 from Cohesion Biosciences
|
||||||||
Blooms Syndrome Protein Blm RNAi - H00000641-R01 from Novus Biologicals
|
||||||||
BLM - MBS8235486 from MyBioSource
|
||||||||
shRNA set against Human BLM (NM_000057.2) - SHH246866 from Creative biogene
|
||||||||
Human BLM siRNA - orb260939 from Biorbyt
|
||||||||
BLM shRNA Plasmid (Human) - CHH0437 from Cohesion Biosciences
|