| Gene Symbol |
Mapkap1
|
| Entrez Gene |
296648
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase associated protein 1
|
| Other Description |
SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mitogen-activated protein kinase 2-associated protein 1|stress-activated map kinase-interacting protein 1|target of rapamycin complex 2 subunit MAPKAP1
|
| Swissprots |
Q6AYF1
|
| Accessions |
Q6AYF1 BC079073 AAH79073 XM_006233949 XP_006234011 XM_006233950 XP_006234012 XM_008761720 XP_008759942 XM_008761721 XP_008759943 XM_008761722 XP_008759944 XM_008761723 XP_008759945 NM_001011964 NP_001011964
|
| Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Nucleus {ECO:0000250}.
|